Mannatech Science

Manna-C

Manna-C™ capsules
Herbal dietary supplement. Gluten-free. Suitable for vegetarians.


    

Ingredients

OpenAloe vera (inner leaf gel powder)

Aloe vera (inner leaf gel powder)

Aloe vera inner leaf gel powder  is the powder obtained from the freeze-dried gel from the leaves of the aloe vera plant, Aloe barbadensis.

For centuries, the plant aloe vera has been used by cultures for its beneficial effects on human health (1). Today aloe vera gel continues to be used in supplements, foods, beverages, and cosmetics. Aloe leaves consist of two major parts, the outer leaf epidermis and the inner leaf gel, which are very different in their chemical composition and properties. Aloe gel is obtained from the inner portion of the leaves. Aloe gel is rich in nutrients and contains an abundant supply of glycoproteins and mono-, oligo- and polysaccharides. Monosaccharide constituents include glucose, mannose, galacturonic acid, glucuronic acid, galactose, arabinose, fucose, glucosamine, fructose, rhamnose and xylose (2).

Much of the health benefits observed by the use of aloe vera gel may be attributed to its high molecular weight polysaccharides. Before a process was developed to stabilize aloe vera gel or extracts, fresh preparations were regarded as being required for any therapeutic efficacy (3). It has now been shown that careful drying of aloe vera gel can retain the polysaccharide content important for producing many of its health benefits (4).

 

This ingredient can be found in the following products:
   •  Advanced Ambrotose® capsules
   •  Advanced Ambrotose® powder
   •  AmbroStart® drink mix
   •  Ambrotose AO® capsules
   •  Ambrotose® Complex capsules
   •  CardioBALANCE® capsules
   •  Catalyst™ caplets
   •  EM•PACT® sports drink
   •  MannaBears™ supplement
   •  Manna-C™ capsules
   •  MannaCLEANSE™ caplets
   •  NutriVerus™ powder
   •  Optimal Support Packets
   •  Phyt-Aloe® capsules or powder
   •  PhytoBurst® Nutritional Chews
   •  PhytoMatrix® caplets
   •  PLUS™ caplets
   •  SPORT™ capsules
 

 

 

References

References

1.  The Merck Index. Whitehouse Station, NJ: Merck & Co., Inc., 1996.

2.  Duncan, C., Ramberg, J., and Sinnott, R. Striking differences in Aloe vera gel carbohydrate composition, molecular weight and particle size distributions following processing will not be addressed by dietary supplement GMPs. Poster Presentation at the 5th Annual Natural Supplements Conference, January 17-20, 2008, Scripps Center for Integrative Medicine, San Diego, California.

3.  Gjerstad G, Riner TD. Current status of aloe as a cure-all. Am J Pharm Sci Support Public Health 1968;140:58-64.

4.  Ni Y, Turner D, Yates KM, Tizard I. Isolation and characterization of structural components of Aloe vera L. leaf pulp. Int J Immunopharmacol. 2004;4:1745-55.

Last updated November 2013

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OpenArabinogalactan (from Larix spp. wood)

Arabinogalactan (from Larix spp. wood)

Arabinogalactans are a class of long, densely branched high-molecular weight polysaccharides extracted for commercial uses from the bark of the Eastern and Western Larch trees, Larix larcinia and Larix occidentalis. Their monosaccharide constituents include galactose, arabinose, glucose and mannose (1). Larch arabinogalactans are considered a good source of soluble dietary fiber. Arabinogalactans are common in many food plants, including corn, carrots, tomatoes, pears, wheat and red wine (2)

The amount of arabinogalactan absorbed through the intestine after an oral dose is unclear. Non-absorbed arabinogalactan is fermented by bacteria in the gastrointestinal tract (3),(4). Larch arabinogalactans are approved by the U.S. Food and Drug Administration (FDA) as generally recognized as safe (GRAS) (21CFR172.610).

This ingredient can be found in the following products:
   •  Advanced Ambrotose® capsules
   •  Advanced Ambrotose® powder
   •  AmbroStart® drink mix
   •  Ambrotose® Complex capsules
   •  Ambrotose® Complex powder
   •  CardioBALANCE® capsules
   •  Catalyst™ caplets
   •  EM•PACT®
   •  Manna-C™ capsules
   •  MannaCLEANSE™ caplets
   •  NutriVerus™ powder
   •  Optimal Support Packets
   •  Phyt-Aloe® capsules or powder
   •  PLUS™ caplets
   •  SPORT™ capsules
 

References

References

 

     1.    Luta G, Duncan C, Sinnott R. Chemical characterization of polysaccharide-rich ingredients from Aloe vera, Larix laricina and Larix occidentalis, and Undaria pinnatifida. Presented at the Scripps Center for Integrative Medicine's 6th Annual Natural Supplements Conference, San Diego, California.January 22-25, 2009. 2009.
     2.    Cui SW. Polysaccharide Gums from Agricultural Products: Processing, Structures & Functionality. Lancaster, Pa.: Technomic Publishing Co., Inc., 2001.
     3.    Crociani F, Alessandrini A, Mucci MM, Biavati B. Degradation of complex carbohydrates by Bifidobacterium spp. Int J Food Microbiol 1994;24:199-210.
     4.    Kelly GS. 'Larch arabinogalactan: clinical relevance of a novel immune-enhancing polysaccharide. Altern.Med Rev 1999;4:96-103.

Last updated March, 2013

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OpenBoneset (aerial part)

Boneset (aerial part)

Boneset, Eupatorium perfoliatum, is an herb native to eastern North America. The flowers and dried leaves have been commonly used to promote health since the 17th century. Boneset contains a number of potentially beneficial compounds, including polysaccharide, phytosterols, and flavonoids such as quercetin and rutin (1).

This ingredient can be found in the following products:
   •  Manna-C™ capsules
 

References

References

1. Natural Standard Database. www.naturalstandard.com. 2009.

Last updated April, 2009

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OpenCatnip (leaf)

Catnip (leaf)

Catnip, Nepeta cataria, is a perennial herb famous for its effects on the behavior of cats. In Kazakhstan, catnip has traditionally been used as an herbal tea. The perceived health benefits of consuming catnip (leaves, tea or oil) are primarily attributed to its chemical component nepetalactone (1). A number of bioflavonoids have also been found in the lemon variety of catnip (2).

This ingredient can be found in the following products:
   •  Manna-C™ capsules
 

References

References

1. Natural Standard Database. www.naturalstandard.com. 2009.

2. Modnicki D, Tokar M, Klimek B. Flavonoids and phenolic acids of Nepeta cataria L. var. citriodora (Becker) Balb. (Lamiaceae). Acta Pol.Pharm 2007;64:247-52.

Last updated April, 2009

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OpenGhatti gum

Ghatti gum

 

Ghatti gum, a mixture of complex polysaccharides, comes from the bark of Anogeissus latifolia, a large tree native to India and Sri Lanka. Monosaccharide constituents include arabinose, galactose, mannose, xylose and glucuronic acid. Ghatti gum is used in supplements, foods, drugs and cosmetics. It contains as much as 80% soluble dietary fiber (1).
 
Most gums are believed to be largely degraded in the colon (2). Test tube studies have demonstrated the fermentation of ghatti gum by the beneficial human bacteria species Bifidobacterium (3),(4). Ghatti gum is considered generally recognized as safe (GRAS) by the U.S. Food and Drug Administration (FDA) and is permitted for use as a food (21CFR184.1333).

 This ingredient can be found in the following products:
   •  Advanced Ambrotose® capsules
   •  Advanced Ambrotose® powder
   •  AmbroStart® drink mix
   •  Ambrotose AO® capsules
   •  Ambrotose® Complex capsules
   •  Ambrotose® Complex powder
   •  CardioBALANCE® capsules
   •  Catalyst™ caplets
   •  EM•PACT® sports drink
   •  Emprizone® gel
   •  FIRM with Ambrotose® cream
   •  Manna-C™ capsules
   •  MannaCLEANSE™ caplets
   •  Optimal Support Packets
   •  Phyt-Aloe® capsules or powder
   •  PLUS™ caplets
   •  SPORT™ capsules
 

References

References

1. Glicksman M. Gum Ghatti (Indian gum). In: Glicksman M, ed. Food Hydrocolloids. Boca Raton: CRC Press 1983:31-7.

2. Hill MJ. Bacterial fermentation of complex carbohydrate in the human colon. Eur J Cancer Prev 1995;4:353-8.

3. Crociani F, Alessandrini A, Mucci MM, Biavati B. Degradation of complex carbohydrates by Bifidobacterium spp. Int J Food Microbiol 1994;24:199-210.

4. Salyers AA, West SE, Vercellotti JR, Wilkins TD. Fermentation of mucins and plant polysaccharides by anaerobic bacteria from the human colon. Appl Environ Microbiol 1977;34:529-33.

Last updated November 2013

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OpenGum tragacanth

Gum tragacanth

Gum tragacanth comes from the stems and branches of the flowering plant Astragalus gummifer. The raw gum is made up of a mixture of two polysaccharides. Monosaccharide constituents include galactose, arabinose, xylose, fucose, rhamnose, and galacturonic acid (1). Gum tragacanth has been approved for use in pharmaceuticals in the U.S. since 1820 and in foods since 1925 (2). Most gums are believed to be largely degraded in the colon (3). Test tube studies have demonstrated that gum tragacanth can be digested by a number of bacteria that inhabit the human colon, including the beneficial Bifidobacteria species (4),(5). Gum tragacanth is generally recognized as safe (GRAS) by the U.S. Food and Drug Administration (FDA) and is commonly added to foods (21CFR184.1351).

This ingredient can be found in the following products:
   •  Advanced Ambrotose® capsules
   •  Advanced Ambrotose® powder
   •  AmbroStart® drink mix
   •  Ambrotose AO® capsules
   •  Ambrotose® Complex capsules
   •  Ambrotose® Complex powder
   •  CardioBALANCE® capsules
   •  Catalyst™ caplets
   •  EM•PACT® sports drink
   •  Emprizone® gel
   •  FIRM with Ambrotose® cream
   •  Manna-C™ capsules
   •  MannaCLEANSE™ caplets
   •  NutriVerus™ powder
   •  Optimal Support Packets
   •  Phyt-Aloe® capsules or powder
   •  PLUS™ caplets
   •  SPORT™ capsules
 

References

References

1. Anderson DM, Howlett JF, McNab CG. The amino acid composition of the proteinaceous component of gum tragacanth (Asiatic Astragalus spp.). Food Addit Contam 1985;2:231-5.

2.  Anderson DM. Evidence for the safety of gum tragacanth (Asiatic Astragalus spp.) and modern criteria for the evaluation of food additives. Food Addit Contam 1989;6:1-12.

3.  Hill MJ. Bacterial fermentation of complex carbohydrate in the human colon. Eur J Cancer Prev 1995;4:353-8.

4.  Crociani F, Alessandrini A, Mucci MM, Biavati B. Degradation of complex carbohydrates by Bifidobacterium spp. Int J Food Microbiol 1994;24:199-210.

5.  Salyers AA, West SE, Vercellotti JR, Wilkins TD. Fermentation of mucins and plant polysaccharides by anaerobic bacteria from the human colon. Appl Environ Microbiol 1977;34:529-33.

Last updated November 2013

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OpenHorehound (aerial part)

Horehound (aerial part)

Horehound, Marrubium vulgare, is an herb native to Europe and Asia. The flowers and dried leaves have been used orally since ancient Egypt and traditionally by Native American and Australian Aboriginal cultures. Horehound contains vitamin C and a number of phytochemicals, including alkaloids, flavonoids, sterols and tannins (1). Horehound and horehound extract are considered generally recognized as safe (GRAS) for use in foods by the U.S. Food and Drug Administration (FDA) (2).

This ingredient can be found in the following products:
   •  Manna-C™ capsules
 

References

References

1. Natural Standard Database. www.naturalstandard.com. 2009.

2. Food and Drug Administration. EAFUS: A Food Additive Database. http://www.foodsafety.gov/~dms/eafus.html. 10-17-2008. 12-4-2008.

Last updated April, 2009

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OpenLemon verbena

Lemon verbena

Lemon verbena is a perennial herb used as an ingredient in herbal teas and other beverages. It is approved for use as a natural flavoring substance in foods by the U.S. Food and Drug Administration (FDA) (21CFR172.510) (1).

This ingredient can be found in the following products:
   •  Manna-C™ capsules
 

References

References

1. Food and Drug Administration. EAFUS: A Food Additive Database. http://www.foodsafety.gov/~dms/eafus.html. 10-17-2008. 12-4-2008.

Last updated April, 2009

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OpenPeppermint (leaf)

Peppermint (leaf)

Peppermint, Mentha piperita, is an herb grown throughout much of Europe and North America. Peppermint (aerial parts and oil) has a long history of traditional use and is a common flavoring agent. It contains menthol, carotene, tocopherols, flavonoids and other polyphenols (1). Peppermint is considered generally recognized as safe (GRAS) by the U.S. Food and Drug Administration (FDA) for use as a natural flavoring (21CFR182.10).

This ingredient can be found in the following products:
   •  GI-ZYME® capsules
   •  Manna-C™ capsules
 

References

References

1. Natural Standard Database. www.naturalstandard.com. 2009.

Last updated March, 2009

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OpenSage (leaf)

Sage (leaf)

Sage, Salvia spp., is an herb that has been used for centuries in Europe as a food spice and for its numerous health benefits. It is sold as dried leaves or as tinctures, fluid extracts and essential oils that are made from the leaves. Sage contains a number of polyphenolic compounds and bioflavonoids, along with beta-carotene and alpha-tocopherol (1). It is considered generally recognized as safe (GRAS) by the U.S. Food and Drug Administration (FDA) for use as a natural seasoning or flavoring substance in foods (21CFR182.10) (2).

This ingredient can be found in the following products:
   •  Manna-C™ capsules
 

References

References

1. Natural Standard Database. www.naturalstandard.com. 2009.

2. Food and Drug Administration. EAFUS: A Food Additive Database. http://www.foodsafety.gov/~dms/eafus.html. 10-17-2008. 12-4-2008.

Last updated April, 2009

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OpenVitamin C (from acerola fruit extract)

Vitamin C (from acerola fruit extract)

Vitamin C, also called ascorbic acid, is an essential water-soluble vitamin found mainly in fruits and vegetables, particularly in citrus fruits such as oranges. Vitamin C functions as a reducing agent and thereby demonstrates potent antioxidant activity. Vitamin C deficiency can lead to the disease scurvy, which involves the deterioration of elastic tissue, demonstrating the important role of ascorbic acid in the synthesis of connective tissues such as collagen in bones (1). Dietary vitamin C is efficiently absorbed through the intestine.
     Vitamin C is generally recognized as safe (GRAS) by the U.S. Food and Drug Administration (FDA) (21CFR182.8013). The U.S. FDA has established a Reference Daily Intake (RDI) of 60 mgs vitamin C for adults and children 4 or more years of age (21CFR101.9). RDIs are a set of dietary references for essential vitamins and minerals that are considered amounts sufficient to meet the daily requirements of healthy individuals. RDIs serve as the basis for calculating the percent daily value (%DV) amounts found on dietary supplement and food labels.
     Acerola extract is obtained from the fruit of the small tree, Malpighia glabra or Malpighia punicifolia. Acerola is grown in tropical regions of the Americas. The fruit is known for being one of the richest natural sources of vitamin C and also contains vitamin A, thiamin, riboflavin, niacin and polyphenols, such as anthocyanins. Acerola fruit extract acts as an antioxidant, likely due to the presence of some of these nutrients (2). Most acerola fruit is processed into fruit products, such as jams, jellies and juices, or added to dietary supplements as a source of vitamin C (3).

This ingredient can be found in the following products:
   •  Manna-C™ capsules
   •  PhytoBurst® nutritional chews
   •  PhytoMatrix® caplets
 

References

References

1. Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, D.C.: National Academy Press, 2000.

2. Natural Standard Database. www.naturalstandard.com. 2009.

3. Ensminger AH, Ensminger ME, Konlande JE, Robson JRK. The Concise Encyclopedia of Foods and Nutrition. Boca Raton, Florida: CRC Press, 1995.

Last updated March, 2009

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OpenWild bush plum (Terminalia ferdinandiana) (fruit w/o seed)

Wild bush plum (Terminalia ferdinandiana) (fruit w/o seed)

Wild bush plum, also known as Australian bush plum or Kakadu plum, is the fruit of a small deciduous tree, Terminalia ferdinandiana, found in northwestern Australia. Kakadu plums have been a food and medicinal source for aboriginal people for thousands of years (1). With an average vitamin C content of 3.0%–3.5% (range = 0.2%–5.9%), the bush plum is believed to be the single natural food source with the highest vitamin C content in the world (2).

This ingredient can be found in the following products:
   •  Manna-C™ capsules
 

References

References

1. Isaacs J. Bush Food. Aboriginal Food and Herbal Medicine. The Rocks, Australia: Landsdowne Publishing Pty Ltd, 1997.

2. Woods B. Kakadu plum (Terminalia ferdinandiana). The Australian New Crops Newsletter (July 10). 1998.

Last updated March, 2009

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OpenYarrow (flower)

Yarrow (flower)

Yarrow, Achillea millefolium, is an herb with a long history of use, dating back to ancient Greece. It contains a number of polyphenols and flavonoid compounds, which may be responsible for the perceived health benefits of yarrow (1). The herb is approved for use as a natural flavoring substance in foods by the U.S. Food and Drug Administration (FDA) (21CFR172.510) (2).

This ingredient can be found in the following products:
   •  Manna-C™ capsules
 

References

References

1. Natural Standard Database. www.naturalstandard.com. 2009.

2. Food and Drug Administration. EAFUS: A Food Additive Database. http://www.foodsafety.gov/~dms/eafus.html. 10-17-2008. 12-4-2008.

Last updated April, 2009

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Formulation Ingredients

OpenSodium starch glycolate

Sodium starch glycolate

Sodium starch glycolate is the sodium salt of a derivative of potato starch. It is used to aid in the disintegration of oral tablets and capsules (1). Sodium starch glycolate is included in the U.S. Food and Drug Administration (FDA) Inactive Ingredients Guide as safe to use in the amounts present in our products (2).

This ingredient can be found in the following products:
   •  Manna-C™ capsules
 

References

References

1. Handbook of Pharmaceutical Excipients. Washington, DC: Pharmaceutical Press and American Pharmacists Assn, 2006.

2. FDA Inactive Ingredients Guide. http://www.accessdata.fda.gov/scripts/cder/iig/index.cfm. 2007.

Last updated April, 2009

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OpenVegetable cellulose

Vegetable cellulose

Vegetable cellulose. Cellulose is a natural compound found in the cell walls of many plants. Powdered cellulose is added to tablets and capsules for a variety of reasons: to dilute the ingredients in tablets or capsules or to help tablets disintegrate following ingestion. Powdered cellulose is not absorbed systemically following oral ingestion and thus has little potential for toxicity. While consumption of large amounts (i.e., 6 g) may have a laxative effect, this is not a concern for individuals consuming the small amounts used as formulation aids in dietary supplements (1).

This ingredient can be found in the following products:
   •  Ambrotose® Complex capsules
   •  BounceBack® capsules
   •  GI-ZYME® capsules
   •  Manna-C™ capsules
   •  Optimal Support Packets
   •  Phyt-Aloe® capsules or powder
 

References

References

1. Handbook of Pharmaceutical Excipients. Gurnee, IL: Pharmaceutical Press, 2006.

Last updated July, 2013

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OpenVegetable stearic acid

Vegetable stearic acid

Stearic acid is a naturally occurring fatty acid that is found in animal and vegetable fats. In dietary supplements, it is typically a combination of stearic and palmitic acids. Stearic acid is used as a lubricantin capsules and tablets and is also used widely in cosmetics and food products (1).Stearic acid is approved by the U.S. Food and Drug Administration (FDA) as generally recognized as safe (GRAS) (21CFR184.1090)and is generally regarded as a nontoxic and nonirritating material (1).

This ingredient can be found in the following products:
   •  Advanced Ambrotose® capsules
   •  ImmunoSTART® tablets
   •  Manna-C™ capsules
 

References

References

1. Handbook of Pharmaceutical Excipients. Gurnee, IL: Pharmaceutical Press, 2006.

Last updated March, 2009

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About Ingredients

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* This statement has not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure or prevent any disease.