Mannatech Science

Accelerator 3

Omega-3 with Vitamin D3
Brain, bone and heart health supplement.* Naturally gluten-free.

Many Americans Would Benefit from Intake of Supplemental Vitamin D Higher than Current RDAs


    

Ingredients

OpenDocosahexaenoic acid (DHA)

Docosahexaenoic acid (DHA)

Docosahexaenoic acid (DHA) is a long-chain polyunsaturated omega-3 (n-3) fatty acid considered to be nutritionally essential to maintain optimal health. There are a number of known health benefits associated with omega-3 fatty acid intake, with most current research focusing on the n-3 fatty acids DHA and EPA (eicosapentaenoic acid). In the body, DHA is an important component of cell membranes, particularly in the brain and retina. However, the human body cannot synthesize omega-3 fatty acids on its own, so these nutrients must be provided by the diet. By consuming the n-3 fatty acid alpha-linolenic acid (ALA) from sources such as flax seed, the body can convert ALA into EPA and eventually DHA, but the low rate of conversion supports direct dietary intake of DHA from foods and dietary supplements (1). The major food sources of DHA, as well as EPA, are algae and cold-water oily fish, such as salmon, herring, mackerel, anchovies and sardines (2). Dietary supplements containing significant amounts of EPA and DHA are typically fish oils derived from these fish. In addition, infant formulas often contain supplemental DHA. The U.S. Food and Drug Administration (FDA) has determined that the use of DHA and EPA omega-3 fatty acids as dietary supplements is safe, provided that the daily intakes of DHA and EPA do not exceed 2 grams per day from dietary supplement sources such as fish oil (3). A major safety concern is the possible presence of heavy metals and toxins, which can be found in relatively high levels in fresh fish and unpurified fish oils. When considering omega-3 DHA and EPA dietary supplements, it is important to look for fish oils that have been purified to reduce the levels of these contaminants.

This ingredient can be found in the following products:
   •  Omega-3 with Vitamin D
 

References

References

1. Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein and Amino Acids. Washington, DC: National Academies Press, 2005.

2. Ensminger AH, Ensminger ME, Konlande JE, Robson JRK. The Concise Encyclopedia of Foods and Nutrition. Boca Raton, Florida: CRC Press, 1995.

3. U.S.Food and Drug Administration. FDA Announces Qualified Health Claims for Omega-3 Fatty Acids. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/2004/ucm108351.htm. 9-8-2004. 8-18-2009.
 

Last updated August, 2011

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OpenEicosapentaenoic acid (EPA)

Eicosapentaenoic acid (EPA)

Eicosapentaenoic acid (EPA) is a long-chain polyunsaturated omega-3 (n-3) fatty acid considered to be nutritionally essential to maintain optimal health. There are a number of known health benefits associated with omega-3 fatty acid intake, with most current research focusing on the n-3 fatty acids EPA and DHA (docosahexaenoic acid). In the body, EPA is an important component of cell membranes where it can be used to generate signaling molecules called eicosanoids or can be converted into DHA. However, the human body cannot synthesize omega-3 fatty acids on its own, so these nutrients must be provided by the diet. By consuming the n-3 fatty acid alpha-linolenic acid (ALA) from sources such as flax seed, the body can convert ALA into EPA, but the low rate of conversion supports direct dietary intake of EPA from foods and dietary supplements (1). The major food sources of EPA, as well as DHA, are algae and cold-water oily fish, such as salmon, herring, mackerel, anchovies and sardines (2). Dietery supplements containing significant amounts of EPA and DHA are typically fish oils derived from these fish. The U.S. Food and Drug Administration (FDA) has determined that the use of EPA and DHA omega-3 fatty acids as dietary supplements is safe, provided that the daily intakes of EPA and DHA do not exceed 2 grams per day from dietary supplement sources such as fish oil (3). A major safety concern is the possible presence of heavy metals and toxins, which can be found in relatively high levels in fresh fish and unpurified fish oils. When considering omega-3 EPA and DHA dietary supplements, it is important to look for fish oils that have been purified to reduce the levels of these contaminants.

This ingredient can be found in the following products:
   •  Omega-3 with Vitamin D
 

References

References

1. Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein and Amino Acids. Washington, DC: National Academies Press, 2005.

2. Ensminger AH, Ensminger ME, Konlande JE, Robson JRK. The Concise Encyclopedia of Foods and Nutrition. Boca Raton, Florida: CRC Press, 1995.

3. U.S.Food and Drug Administration. FDA Announces Qualified Health Claims for Omega-3 Fatty Acids. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/2004/ucm108351.htm. 9-8-2004. 8-18-2009.

Last updated August, 2011

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OpenMixed tocopherols

Mixed tocopherols

Mixed tocopherols are organic compounds collectively known as vitamin E. Natural tocopherols exist as a mixture of d-alpha-, d-beta-, d-gamma- and d-delta-isoforms, each having antioxidant activities (1). Tocopherols are present in many foods, such as vegetable oils, nuts and grains. They are considered generally recognized as safe (GRAS) by the U.S. Food and Drug Administration (FDA) for use in foods (21CFR182.3890) (2).

This ingredient can be found in the following products:
   •  Ambrotose AO® capsules
   •  CardioBALANCE® capsules
   •  Catalyst™ caplets
   •  Omega-3 with Vitamin D
   •  Optimal Support Packets
   •  PhytoBurst® nutritional chews
   •  PhytoMatrix® caplets
 

References

References

1. Yoshida Y, Saito Y, Jones LS, Shigeri Y. Chemical reactivities and physical effects in comparison between tocopherols and tocotrienols: physiological significance and prospects as antioxidants. J Biosci Bioeng. 2007;104:439-45.

2. Food and Drug Administration. EAFUS: A Food Additive Database. http://www.foodsafety.gov/~dms/eafus.html. 10-17-2008. 12-4-2008.
 

Last updated March, 2013

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OpenOmega-3 fatty acids

Omega-3 fatty acids

Omega-3 (n-3) fatty acids generally refer to the nutritionally essential polyunsaturated fatty acids (PUFAs) alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). Fatty acids are the building blocks of lipids, making them important sources of energy for the body and the main components of cell membranes (1). There are a number of known health benefits associated with omega-3 fatty acid intake, with most current research focusing on the longer chain n-3 PUFAs EPA and DHA. However, the human body cannot synthesize n-3 fatty acids on its own, and so these nutrients must be provided by the diet (1). Food sources of ALA include flax seed, hemp seed, walnut, canola, soy bean, and dark green leaves, while the major sources of EPA and DHA are algae and cold-water oily fish, such as salmon, herring, mackerel, anchovies and sardines (2).
     Dietary unsaturated fatty acids are well absorbed through the intestine and into the bloodstream. The Institute of Medicine has established an adequate intake of 1.6 g/day ALA for men and 1.1 g/day ALA for women (1). The body can form EPA and DHA from ALA, but the low rate of conversion supports direct dietary intake of EPA and DHA. The U.S. Food and Drug Administration (FDA) has determined that the use of EPA and DHA omega-3 fatty acids as dietary supplements is safe, provided that the daily intakes of EPA and DHA do not exceed 2 grams per day from dietary supplement sources such as fish oil (3). A major safety concern is the possible presence of heavy metals and toxins, which can be found in relatively high levels in fresh fish and unpurified fish oils. When considering omega-3 EPA and DHA dietary supplements, it is important to look for fish oils that have been purified to reduce the levels of these contaminants.

This ingredient can be found in the following products:
   •  Omega-3 with Vitamin D
 

References

References

1. Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein and Amino Acids. Washington, DC: National Academies Press, 2005.

2. Ensminger AH, Ensminger ME, Konlande JE, Robson JRK. The Concise Encyclopedia of Foods and Nutrition. Boca Raton, Florida: CRC Press, 1995.

3. U.S.Food and Drug Administration. FDA Announces Qualified Health Claims for Omega-3 Fatty Acids. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/2004/ucm108351.htm. 9-8-2004. 8-18-2009.
 

Last updated August, 2011

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OpenVitamin D3

Vitamin D3

Vitamin D3 (cholecalciferol) is a fat-soluble vitamin that is synthesized by humans in the skin when exposed to ultraviolet-B (UVB) rays from sunlight. Vitamin D3 is the most frequently recommended form of supplemental vitamin D (1). Current average daily intakes of vitamin D for Americans are well below suggested adequate intakes (2), and much of the world’s population is deficient in this important vitamin (3).
    The main function of vitamin D is to regulate blood calcium and phosphorus concentrations by enhancing the efficiency of the small intestine to absorb these minerals. By influencing the absorption of calcium, vitamin D thus helps to form and maintain strong bones and teeth (4),(5). Vitamin D supplementation helps prevent falls and maintain physical performance in the elderly (5),(6). Adequate vitamin D intake may also be important for maintaining immune health (7),(8), nervous system health (9), may help improve mood during the winter months (10),(11) and improve overall quality of life (12).
    Vitamin D is generally well tolerated at recommended doses. The U.S. Food and Drug Administration (FDA) has established a Reference Daily Intake (RDI) of 600 international units (IUs) vitamin D for individuals ages 1-70 and 800 IUs for adults >70 years. RDIs are a set of dietary references for essential vitamins and minerals that are considered amounts sufficient to meet the daily requirements of healthy individuals. They serve as the basis for calculating the percent daily value (% DV) amounts found on dietary supplement and food labels.
    According to the Endocrine Society’s Vitamin D Clinical Practice Guidelines, published in June 2011, individuals who are at risk for vitamin D deficiencies should as their physician to have their blood tested for the vitamin D metabolite [25(OH)D]. For individuals with blood 25(OH)D levels <75 nmol/L, higher amounts of vitamin D intake are suitable: children ages 1–18 may need 600–1,000 IU daily, adults >18 age may need 1,500–2,000 IU vitamin D daily (13).

 Many Americans Would Benefit from Intake of Supplemental Vitamin D Higher than Current RDAs


This ingredient can be found in the following products:
   •  Catalyst™ caplets
   •  Omega-3 with Vitamin D3
 

References

References

1. USDA Dietary Guidelines Advisory Committee. Report of the Dietary Guidelines Advisory Committee on the Dietary Guidelines for Americans, 2010. 2010.

2. Mithal A, Wahl DA, Bonjour JP et al. Global vitamin D status and determinants of hypovitaminosis D. Osteoporos.Int 2009;20:1807-20.

3. Palacios C. The role of nutrients in bone health, from A to Z. Crit Rev Food Sci Nutr 2006;46:621-8..

4. Institute of Medicine. Dietary Reference Intakes for Calcium and Vitamin D. 2010.

 5. Annweiler C, Montero-Odasso M, Schott AM, Berrut G, Fantino B, Beauchet O. Fall prevention and vitamin D in the elderly: an overview of the key role of the non-bone effects. J Neuroeng.Rehabil. 2010;7:50.

6. van Etten E, Mathieu C. Immunoregulation by 1,25-dihydroxyvitamin D3: basic concepts. J Steroid Biochem Mol Biol 2005;97:93-101.

7. Maggini S, Wintergerst ES, Beveridge S, Hornig DH. Selected vitamins and trace elements support immune function by strengthening epithelial barriers and cellular and humoral immune responses. Br J Nutr 2007;98 Suppl 1:S29-S35. .

8. McCann JC, Ames BN. Is there convincing biological or behavioral evidence linking vitamin D deficiency to brain dysfunction? FASEB J 2008;22:982-1001.

9. Bertone-Johnson ER. Vitamin D and the occurrence of depression: causal association or circumstantial evidence? Nutr Rev 2009;67:481-92. 10. .

10. Lansdowne AT, Provost SC. Vitamin D3 enhances mood in healthy subjects during winter. Psychopharmacology (Berl) 1998;135:319-23. .

11. Norman AW, Bouillon R. Vitamin D nutritional policy needs a vision for the future. Exp Biol Med (Maywood.) 2010;235:1034-45.

12. Holick MF, Binkley NC, Bischoff-Ferrari HA et al. Evaluation, treatment, and prevention of vitamin d deficiency: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 2011;96:1911-30.

Last updated March, 2013

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Formulation Ingredients

OpenKosher gelatin

Kosher gelatin

Kosher gelatin. Gelatin is a protein derived from animal collagen, usually from cow or pig skin and bones. In order for a food to be classified as kosher, the ingredients, preparation and processing facilities must all meet kosher standards. Gelatin is a commonly used gelling agent in foods and can also be used to form hard or soft gelatin capsules for oral products (1). Gelatin is approved for use as a food additive by the U.S. Food and Drug Administration (FDA) (2).

This ingredient can be found in the following products:
   •  Omega-3 with Vitamin D
 

References

References

1. Handbook of Pharmaceutical Excipients. Washington, DC: Pharmaceutical Press and American Pharmacists Assn, 2006.

2. Food and Drug Administration. EAFUS: A Food Additive Database. http://www.foodsafety.gov/~dms/eafus.html. 10-17-2008. 12-4-2008.
 

Last updated August, 2011

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OpenNatural lemon flavor

Natural lemon flavor

Natural lemon flavor is oil extracted from the flavoring constituents of lemons, primarily the peels. Its significant function in food is flavoring rather than nutritional (21CFR501.22).

This ingredient can be found in the following products:
   •  Omega-3 with Vitamin D
   •  PhytoBurst® nutritional chews
 

References

References

  

Last updated August, 2011

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OpenPurified fish oil concentrate

Purified fish oil concentrate

Purified fish oil concentrate. Commercial fish oils marketed as dietary supplements are typically derived from fresh, cold-water, oily fish, such as salmon, herring, mackerel, anchovies and sardines (1). The use of fish oil supplements is intended to provide the body with the essential omega-3 fatty acids, EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid). Concentrated fish oils tend to contain higher amounts of EPA and DHA. While consuming fatty fish can also provide these omega-3 fatty acids, most individuals do not consume the required servings. In addition, much of the available fish today is raised on farms rather than in their native water habitats, greatly reducing their concentrations of EPA and DHA. Furthermore, cold-water fish can contain dangerous amounts of environmental pollutants, such as mercury, PCBs (polychlorinated biphenyls) and dioxins (2). A major safety concern is the possible presence of these polluntants, which can be found in relatively high levels in fresh fish and unpurified fish oils. When considering omega-3 EPA and DHA dietary supplements, it is important to look for fish oils that have been purified to reduce the levels of these contaminants. The most common molecular distillation and steam deodorization techniques use a combination of pressure and high temperatures to remove environmental pollutants from fish oil supplements so that they may pass global regulatory standards (3).

This ingredient can be found in the following products:
   •  Omega-3 with Vitamin D3 capsules
 

References

References

1. Ensminger AH, Ensminger ME, Konlande JE, Robson JRK. The Concise Encyclopedia of Foods and Nutrition. Boca Raton, Florida: CRC Press, 1995.

2. Mozaffarian D, Rimm EB. Fish intake, contaminants, and human health: evaluating the risks and the benefits. JAMA 2006;296:1885-99.

3. Environmental Defense Fund. How Safe Are Fish Oil Supplements. http://www.edf.org/page.cfm?tagID=19376. 1-20-2008. 8-19-2009.
 

Last updated November 2013

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About Ingredients

Learn more about:

 
    NSF- Certified according to the NSF/ANSI 173 Dietary Supplement Standard—the only American National Standard for dietary supplements. This certification ensures that this product contains only the ingredients indicated on the label and is free of impurities, and that Good Manufacturing Practices (GMPs) were used in the manufacturing facility.
Read more about NSF

 

* This statement has not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure or prevent any disease.

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