Mannatech Science
Publications

Publications

Publications related to Mannatech's products are listed below. Many of these publications can also be accessed from the U.S. National Library of Medicine's database, PubMed


Book Chapters 

Saccharide Research

Ambrotose® Product Ingredient Studies
    • Human Double-Blind, Placebo-Controlled Trials
    • Basic Science

Ambrotose® Product Studies
    • Human Double-Blind, Placebo-Controlled Trials
    • Human Open-Label Trials
    • Pre-Clinical Studies

Ambrotose AO® capsules
    • Human Double-Blind, Placebo-Controlled Trials
    • Human Open-Label Trials

BounceBack® Capsule Studies
    • Human Randomized, Double-Blind, Placebo-Controlled Crossover Trial

EMPACT™ Sports Drink Studies
    • Human Double-Blind, Placebo-Controlled Trials

Multiple Product Studies
    • Human, Open-Label Trial

OsoLean® Powder Studies
    • Human Open-Label Trial
    • Human Randomized, Double-Blind, Parallel Arm Study

 


 


Book Chapters

Sinnott R, Ramberg JE (2012) Dietary Supplements. Making Good Choices. Nutrition and Personal Health Coaching. Pearson Learning Solutions, Boston, Massachusetts.
Download Chapter PDF


Saccharide Research

Scientists evaluate the ability of oral polysaccharides to promote brain function and behavior.

Nelson ED, Ramberg JE, Best T, Sinnott RA (2012) Neurologic effects of exogenous saccharides: A review of controlled human, animal, and in vitro studies. Nutritional Neuroscience, 1-14.
Read publication. Note: This article can also be accessed from PubMed.

Nelson ED, Ramberg JE, Sinnott RA (2011) A review of human and animal studies assessing the effects of oral polysaccharides on cognitive function and mood. Presented at the Scripps Center for Integrative Medicine’s 8th Annual Natural Supplements Conference, San Diego, California. January 13–16.
Download Research PDF

Scientists report that intake of glyconutrient sugars from foods by 1183 middle-aged adults was associated with improved self-reported memory performance.

Best T, Kemps E, Bryan J (2008) Association between dietary saccharide intake and self-reported memory performance in middle-aged adults. Br J Nutr 101:93-99.
Read publication. Note: This article can also be accessed from PubMed.

In this study of 42 young adults and 42 middle-aged adults, food intake of saccharides was positively correlated with verbal memory recall in middle-aged subjects.

Best T, Kemps E, Bryan J (2007) A role for dietary saccharide intake in cognitive performance. Nutr Neurosci 10:113-20.
Read abstract. Note: This article can be accessed from PubMed.

Scientists describe a role for saccharides in the brain and hypothesize how they might influence cognitive performance.

Best T, Kemps K, Bryan J (2005) Effects of saccharides on brain function and cognitive performance. Nutr Rev 63(12):409-418.
Read abstract. Note: This article can be accessed from PubMed.

Mannatech scientists review the literature regarding the immunomodulatory effects of orally ingested polysaccharides.

Ramberg JE, Nelson ED, Sinnott RA (2010) Immunomodulatory dietary polysaccharides: a systematic review of the literature. Nutr J, 9 (54):1-60.
Read publication. Note: This article can also be accessed from PubMed.

Ramberg JE, Nelson ED, Sinnott RA (2010)  Immunomodulatory polysaccharides: A review of human oral studies. Presented at the Scripps Center for Integrative Medicine’s 7th Annual Natural Supplements Conference, La Jolla, California. January 21-24.
Download Research PDF

Dr. Robert Murray, Professor Emeritus of Biochemistry at the University of Toronto, Canada, and Mannatech scientists review the literature regarding possible mechanisms of action for glyconutrients. 

Murray  RK, Sinnott R, Ramberg J, et al. (2006) Recent dietary carbohydrate utilization research provides insights into the health effects of glyconutritional supplements. Presented at the Scripps Center for Integrative Medicine’s 3rd Annual Natural Supplements Conference, La Jolla, California. January 20-22.
Download Research PDF

Back to top

Ambrotose® Product Ingredients

Human Double-Blind, Placebo-Controlled Trials

In a randomized, double-blind, placebo-controlled trial of 199 healthy adults who had a history of colds, 12 weeks of 4.5g/day larch arabinogalactan tended to reduce the incidence of colds. The number of participants affected by a cold was significantly reduced by arabinogalactan supplementation. (Note: Ambrotose products contain less than 4.5 g arabinogalactan).

Riede L, Grube B, Gruenwald J (2013) Larch arabinogalactan effects on reducing incidence of upper respiratory infections. Curr Med Res Opin 29:251-258.
Read publication. Note: This article can be accessed from PubMed.

In a randomized, double-blind, placebo-controlled trial of 75 health adults, intake of 1.5 g/day larch arabinogalactan significantly increased the IgG antibody response to a tetanus vaccine.

Udani JK (2013) Immunomodulatory effects of ResistAid: A randomized, double-blind, placebo-controlled, multidose study. J Am Coll Nutr 32:331-338.
Read publication. Note: This article can be accessed from PubMed.

In a randomized, double-blind, placebo-controlled trial of 45 healthy adults, intake of 4.5 g/day larch arabinogalactan significantly increased the antibody response to a pneumococcal vaccine. (Note: Ambrotose products contain less than
4.5 g arabinogalactan).

Udani JK, Singh BB, Barrett ML, Singh VJ (2010). Proprietary arabinogalactan extract increases antibody response to the pneumonia vaccine: a randomized, double-blind, placebo-controlled, pilot study in healthy volunteers. Nutr J 9:1-7.
Read publication. Note: This article can be accessed from PubMed.

Basic Science

Mannatech sponsored this research, conducted by outside experts, to determine the chemical profile (MW and total carbohydrate and protein content) and carbohydrate composition (total sugars and free sugars) of aloe vera powder, aloe vera extract, larch arabinogalactan, and Undaria pinatifida extract. 

Luta G, Duncan C, Sinnott R (2009) Chemical characterization of polysaccharide-rich ingredients from Aloe vera, Larix laricina and Larix occidentalis, and Undaria pinatifida. Presented at the Scripps Center for Integrative Medicine's 6th Annual Natural Supplements Conference, San Diego, California. January 22-25.
Download Research PDF

Mannatech scientists conducted this test tube study to better understand the breakdown of Ambrotose® products’ constituent polysaccharides in the gut. They reported which GI tract bacterial glycosylhydrolases could break down aloe vera powder and Undaria pinnatifida extract (in Advanced Ambrotose® products), aloe vera extract (in Ambrotose® complex), and larch arabinogalactan, gum ghatti and gum tragacanth (in both Ambrotose® products). 

Duncan CL, Luta G, Ramberg J, et al. (2009) Intestinal microbiota's naturally occurring enzymes and their effects on plant polysaccharide digestion. Presented at the Scripps Center for Integrative Medicine's 6th Annual Natural Supplements Conference, San Diego, California. January 22-25.
Download Research PDF

Mannatech scientists conducted this study, showing that the processing of aloe vera gel significantly impacts its saccharide composition and molecular weight and particle size distributions. These changes, which likely affect product quality and efficacy, suggest that dietary supplement GMPs will not adequately control aloe gel product quality.

Duncan C, Ramberg J, Sinnott R (2008) Striking differences in aloe vera gel carbohydrate composition, molecular weight and particle size distributions following processing will not be addressed by dietary supplement GMPs. Presented at the Scripps Center for Integrative Medicine’s 5th Annual Natural Supplements Conference, San Diego, California. January 17-20.
Download Research PDF

Dr. John Kalns and colleagues (Hyperion Biotechnology, Inc., San Antonio, TX) developed an in vitro method that showed promise in predicting the immunostimulatory properties of different aloe vera gel preparations.* Study was at least partially funded by Mannatech.

Kalns J, Kirchner J, Ebong S, Oubre C (2007) A sensitive in vitro method for evaluation of immunostimulatory properties of natural products. Presented at the Scripps Center for Integrative Medicine’s 4th Annual Natural Supplements Conference, La Jolla, California. January 19-21.
Download Research PDF

Bonakdar RA (2007) Report on the 4th Annual Natural Supplements Research Competition. J Alt Comp Med 13, 686-87.

Back to top

Ambrotose® Product Studies

Human Double-Blind, Placebo-Controlled Trials

In a randomized, double-blind, placebo-controlled trial of 73 healthy middle-aged adults, Dr. Talitha Best and colleagues from the University of South Australia and Swinburne University of Technology showed that, shortly after taking a single 4-gram serving of classic Ambrotose® complex powder, subjects experienced significantly improved memory and performed significantly better on demanding cognitive tasks. The product had no effect on blood glucose levels.* Study was at least partially funded by Mannatech.

Best T, Howe P, Bryan J, Buckley J, Scholey A (2014) Acute effects of a dietary non-starch polysaccharide supplement on cognitive performance in healthy middle-aged adults. Nutr Neurosci .1-11.
Read abstract. Note: This article can be accessed from PubMed.

Dr. Talitha Best (University of South Australia [UniSA] and Swinburne University of Technology), Associate Professor Eva Kemps (Flinders University) and Dr. Janet Bryan (UniSA) showed that, in a randomized, double-blind, placebo-controlled trial involving more than 100 healthy adults, individuals who consumed Ambrotose® complex powder reported numerous health and well-being benefits following 12 weeks of intake, compared with subjects taking a placebo. Gastrointestinal effects were also among the perceived benefits reported by individuals who consumed Ambrotose complex powder.* Study was at least partially funded by Mannatech.

Best T, Kemps E, Bryan J (2012) Perceived changes in well-being following polysaccharide intake in middle-aged adults. Applied Res Qual Life, 7(2):163-82.
Read publication

Dr. Talitha Best (Flinders University, Adelaide, Australia) showed, in a trial of 109 healthy middle-aged male and female adults, that Ambrotose® complex powder (4 grams/day for 12 weeks) significantly improved memory and improved psychological well-being.*

Best T, Kemps E, Bryan J (2010) Saccharide effects on cognition and well-being in middle-aged adults: A randomized controlled trial. Developmental Neuropsychology 35(1):66-80.
Download Research PDF
Note: This article can also be accessed from PubMed.

Drs. Atiya N. Stancil and Leslie H. Hicks, both of Howard University in Washington, D.C., published this randomized, double-blind, placebo-controlled study investigating the impact of Ambrotose® complex on the brain function of 62 healthy young adults. The study showed that a single, one-tablespoon serving of Ambrotose complex significantly improved visual discrimination and working memory. Study was at least partially funded by Mannatech.

Stancil AN, Hicks LH (2009) Glyconutrients and perception, cognition, and memory. Perceptual Mot Skills 10:259-270.
Download Research PDF
Note: This article can also be accessed from PubMed.

Dr. Talitha Best (Flinders University, Adelaide, Australia) showed that, in a trial of 45 middle-aged male and female subjects, a single 7 gram serving of Ambrotose® complex powder suggested potential enhancement effects of memory performance.* (Note: this serving is 1.75 times the recommended dose [4 grams/day] for this product). Study was at least partially funded by Mannatech.

Best T (2008) An investigation of saccharide effects on memory performance. J Nutr, Health and Aging 12(9)657-662.
Download Research PDF
This article can be accessed from PubMed.

Drs. Chenghua Wang (Rotman Research Institute, Toronto, Canada), Joanne Szabo (University of Arkansas for Medical Sciences, Little Rock, ARK) and Roscoe Dykman (Arkansas Children’s Nutrition Center, Little Rock, ARK) showed, in a study of 20 healthy adults, that a one tablespoon serving of Ambrotose® complex powder enhanced brainwave frequencies known to be associated with attention or alertness.* Study was at least partially funded by Mannatech.

Wang C, Szabo JS, Dykman RA (2004) Effects of a carbohydrate supplement upon resting brain activity. Integr Physiol Behav Sci 39:126-138.
Download Research PDF
Note: This article can also be accessed from PubMed.

Drs. Chenghua Wang and R.T. Pivik (University of Arkansas, Little Rock, ARK) showed, in a study of 20 healthy adults, that a one tablespoon serving of Ambrotose® complex powder had a positive effect on brain waves associated with information processing.* Study was at least partially funded by Mannatech.

Wang C, Pivik RT, Dykman RA (2002)  Effects of a glyconutritional supplement on brain potentials associated with language processing. Federation Proceedings: Experimental Biology Meeting, New Orleans, Louisiana. April 20-24.
Download Research PDF

Human Open-Label Trials

In an open-label human dosing study, Dr. Azita Alavi, a Research Fellow at the Sir Joseph Hotung Centre for Musculoskeletal Disorders, Division of Cellular and Molecular Medicine, St. George’s University of London, U.K. and colleagues showed that intake of Advanced Ambrotose® powder resulted in a significant shift towards increased sialylation in the N-glycosylation profile of the serum of healthy adults. To the authors’ knowledge, this is the first study which has shown that dietary changes can affect serum glycosylation profiles. Co–authors include St. George’s University researchers Professor John Axford, Dr. Edward Tarelli and Dr. Owen Fraser, and Professor Martin Bland, Department of Health Sciences, University of York, UK. Study was at least partially funded by Mannatech.

Alavi A, Fraser O, Tarelli E, Bland M, Axford J. (2011) An open-label dosing study to evaluate the safety and effects of a dietary plant-derived polysaccharide supplement on the N-glycosylation status of serum glycoproteins in healthy subjects. Eur J Clin Nutr, 1-9.
Read publication. Note: This article can also be accessed from PubMed.

Pre-Clinical Studies

Scientists at ProDigest in collaboration with the Laboratory of Microbial Ecology and Technology (LabMET) at Ghent University, in Belgium conducted this study, the first to apply 16sRNA genes-based pyrosequencing in a Simulator of the Human Intestinal Microbial Ecosystem (SHIME) study. The pyrosequencing technique allowed the scientists to explore more deeply and confirm findings from a previous Ghent University study which showed that Advanced Ambrotose powder exhibited prebiotic effects along the entire colon. Study was at least partially funded by Mannatech.

Marzorati M, Maignien L, Verhelst A et al. (2013) Barcoded pyrosequencing analysis of the microbial community in a simulator of the human gastrointestinal tract showed a colon region-specific microbiota modulation for two plant-derived polysaccharide blends. Antonie Van Leeuwenhoek. 103(2):409-20.
Read publication. Note: This article can also be accessed from PubMed.

Mannatech sponsored this research, conducted by outside experts, which showed that intake of Advanced Ambrotose® powder had positive effects in the brain on the expression of genes associated with the regulation of learning, memory and mood (1)*. These preliminary findings are compatible with multiple controlled human clinical studies which indicate that intake of Ambrotose products provides significant cognitive benefits to healthy adults.*

Nelson EN, Ramberg JE, Sinnott RA. (2012) Brain-specific effects of Ambrotose® products: a preliminary animal study to investigate cognitive benefits found in humans. Poster Presentation at the 10th Jenner Glycobiology and Medicine Symposium, The Hague, the Netherlands, March 31-April 3.
Download Poster PDF

Drs. Massimo Marzorati and Sam Possemiers (University of Ghent and ProDigest, Ghent, Belgium) and their colleagues employed state‐of‐the‐art human gastrointestinal tract simulations and microbiological analyses to show that Ambrotose® complex and Advanced Ambrotose® powder exerted positive prebiotic effects.* Both products exhibited good selective fermentability throughout the entire colon and positive and selective bifidogenic effects. They also demonstrated the possibility of enhancing species belonging to Bacteroidetes, a phylum recently associated with body weight management.* Study was at least partially funded by Mannatech.

Marzorati M, Verhelst A, Luta G et al. (2010) In vitro modulation of the human gastrointestinal microbial community by plant-derived polysaccharide-rich dietary supplements. Int J Food Microbiol 139(3):168-76.
Read abstract. Note: This article can also be accessed from PubMed.

Dr. John Kalns and colleagues (Hyperion Biotechnology, Inc., San Antonio, TX) conducted an in vitro study demonstrating that human fecal bacteria can partially break down Advanced Ambrotose® powder and two of its constituents (aloe vera gel polysaccharides and arabinogalactan). Bacteria identified that could best compete for these polysaccharides were Enterococcus species (a species that is a popular probiotic in some countries). Study was at least partially funded by Mannatech.

Sinnott RA, Kalns JE, Boyd S et al. (2007) Human colonic bacteria can utilize the large polysaccharides of aloe vera gel and arabinogalactan polysaccharides as their only carbon source. Presented at the 107th American Society for Microbiology Meeting, Toronto, Canada. May 21-25.
Download Research PDF

Sinnott RA, Ramberg J, Kirchner JM, et al.  (2007) Utilization of arabinogalactan, aloe vera gel polysaccharides, and a mixed saccharide dietary supplement by human colonic bacteria in vitro . Int J Probiotics Prebiotics 2:97-104.

Bonakdar RA (2007) Report on the 4th Annual Natural Supplements Research Competition. J Alt Comp Med 13:686.

Back to top

Ambrotose AO® Capsules Studies

Human Double-Blind, Placebo-Controlled Trial

In a 21-day randomized, double‐blind, placebo‐controlled crossover trial of 25 healthy adults, scientists from the University of Memphis showed that Ambrotose AO capsules significantly increased two measures of antioxidant capacity in the blood: oxygen radical absorbance capacity (ORAC) and Trolox Equivalent Antioxidant Capacity (TEAC).* Study was at least partially funded by Mannatech.

Bloomer RJ, Canale RE, Blankenship MM, Fisher-Wellman KH. (2010) Effect of Ambrotose AO® on resting and exercise-induced antioxidant capacity and oxidative stress in healthy adults. Nutrition Journal, 9:49. doi:10.1186/1475-2891-9-49.
Read publication. Note: This article can also be accessed from PubMed.

McCarthy CG, Canale RE, Fisher‐Wellman KH, Bloomer RJ (2010) Effect of blended antioxidant supplement on resting and exercise‐induced antioxidant capacity and oxidative stress. Presented at the American College of Sports Medicineʹs 57th Annual Meeting, Baltimore, Maryland, June 2–5.

Human Open-Label Trials

In a five-week combined Phase 1 and 2 open label, forced titration dose response study of 21 healthy adults, physicians and scientists from Australia and New Zealand showed that four capsules/day of the Ambrotose AO® dietary supplement appear to be safe and raised serum oxygen radical absorption capacity (ORAC) by 36.6%.* Study was at least partially funded by Mannatech.

Myers SP, Stevenson L, Cheras PA, et al. (2010) A forced titration study of the antioxidant and immunomodulatory effects of Ambrotose AO supplement. BMC Comp Alt Med 10, doi: 10.1186/1472-6882-10-16.
Note: This article can also be accessed from PubMed.

Mannatech scientists and an independent statistician showed, in pilot study of 12 healthy adults, that 2 capsules/day Ambrotose AO® capsules increased serum ORAC (a measure of antioxidant protection) by 37.4% compared with baseline (before supplementation) serum ORAC values.* Study was at least partially funded by Mannatech.

Boyd S, Gary K, Koepke, et al. (2003) An open-label pilot study of the antioxidant effect in healthy people of Ambrotose AO . GlycoScience & Nutrition 4:1-6.
Download Research PDF

Back to top

BounceBack® Capsule Studies

Human Randomized, Double-Blind, Placebo-Controlled Crossover Trial

Dr. Jay Udani (UCLA Geffen School of Medicine, Los Angeles, California and Medicus Research LLC, Northridge, California), and Drs. Betsy Singh, Vijay Singh and Elizabeth Sandoval (Medicus Research LLC) showed that 10 healthy adults experienced reduced pain and tenderness following eccentric exercise after 30 days of supplementation with BounceBack® capsules (2 /day).* Study was at least partially funded by Mannatech.

Udani J, Singh B, Singh V (2009) BounceBack capsules for reduction of DOMS after eccentric exercise: a randomized, double-blind, placebo-controlled, crossover pilot study. J Int Soc Sports Nutr 6(14):1-6.
Download Research PDF
Note: This article can also be accessed from PubMed.

Udani J, Singh B, Singh V, Sandoval E (2008) Effect of a combination dietary supplement product (BounceBack) on the signs and symptoms of delayed onset muscle soreness after eccentric exercise: a randomized, double-blind, placebo-controlled, crossover pilot study. Poster presentation at the 5th Annual International Society of Sports Nutrition Conference, June 8-10, Las Vegas, Nevada.
Download Research PDF

Back to top

EMPACT™ Sports Drink Studies

Human Double-Blind, Placebo-Controlled Trials

Dr. Allyn Byars (Angelo State University, San Angelo, TX), Dr. Susan Keith (Angelo State University) and their colleagues showed that a single serving of creatine-free EM•PACT sports drink significantly improved subjects’ maximal oxygen consumption (VO2max), time to exhaustion and percentage estimated non-protein fat substrate utilization [1]. Study was at least partially funded by Mannatech.

Byars A, Keith S, Simpson W, et al. (2010) The influence of a pre-exercise sports drink (PRX) on factors related to maximal aerobic performance. J Int Soc Sports Nutr 7:1-6.
Download Research PDF
Note: This article can also be accessed from PubMed.

Byars A, Keith S, Snowden S (2009) The influence of a pre-exercise sports drink on indices of aerobic power. Presented at the Scripps Center for Integrative Medicine's 6th Annual Natural Supplements Conference, San Diego, California. January 22-25.
Download Research PDF

Dr. Allyn Byars, Kelly D. Schneider, Mandy C. Hesseltine (Angelo State University ), Dr. Warren K. Simpson (Hardin-Simmons University, Abilene, TX), and Dr. Mike Greenwood (Baylor University, Waco, TX) EM-PACT consumed prior to exercise, enhanced aerobic performance compared to the nation’s leading sports drink in healthy subjects.* Study was at least partially funded by Mannatech.

Byars A, Schneider KD, Hesseltine MC, et al. (2007) Sports nutrition: comparing two sports drinks on aerobic performance. Appl Res Coach Athletics Ann 22:226-240.

Schneider K, Hessletine M, Greenwood, MA (2006) Comparison of two sport drinks on aerobic performance. Presented at the Annual International Society of Sports & Nutrition Conference, June 15-17.

Dr. Allyn Byars (Angelo State University, San Angelo, TX), Drs. Mike and Lori Greenwood (Baylor University, Waco, TX) and Dr. Warren K. Simpson (Hardin-Simmons University, Abilene, TX) showed that, when consumed by healthy subjects instead of water prior to exercise, EMPACT™ sports drink enhanced indices of cardiorespiratory fitness (specifically VO2max and time to exhaustion).* Study was at least partially funded by Mannatech.

Byars  A, Greenwood MGL (2006) The effectiveness of a pre-exercise performance drink (PRX) on indices of maximal cardiorespiratory fitness. J Int Soc Sports Nutr 3: 56-59.
Download Research PDF
Note: This article can also be accessed from PubMed.

Back to top

Multiple Product Studies

Human Open-Label Trial

In a six-month, open-label human studyof 15 retired football players, intake of Mannatech products resulted in statistically significant improvements in numerous self-reported measures of physical and mental health, quality of life, memory, and elbow and knee pain reduction. Study participants took Mannatech’s Ambrotose® complex powder, Omega–3 with Vitamin D3 capsules, Ambrotose AO® capsules, PhytoMatrix® caplets and PLUS caplets. All of these products are gluten-free and NSF-certified. Authors include Mannatech scientists Drs. Robert A. Sinnott and Rolando L. Maddela, Dr. Sejong Bae of the University of North Texas Health Science Center and Dr. Talitha Best of the University of South Australia, Adelaide. Study was at least partially funded by Mannatech.

Sinnott RA, Maddela RL, Bae S, Best T. (2013) The effect of dietary supplements on the quality of life of retired professional football players. Global J Health Sci 2(5):13-26.
Read publication. Note: This article can also be accessed from PubMed.

Sinnott RA, Maddela RL, Bae S, Best T. (2012) Dietary supplementation and the quality of life of retired football players. Poster presentation at the International Society of Sports Nutrition's 9th Annual Conference, Clearwater Beach, Florida, June 22-23.
Read publication
Download Research PDF

Back to top

OsoLean® Powder Studies

Human Open-Label Trial

In a study conducted by Mannatech scientists and an independent statistician, eight weeks of OsoLean® powder consumption significantly increased weight loss and waist inches lost, significantly decreased BMI and appetite, and improved quality of life.* Study was at least partially funded by Mannatech.

Sinnott RA, Maddela RL, Nelson ED, et al. (2009) Preliminary study on the effects of a calcium-rich whey protein supplement (OsoLean® powder) on weight loss, waist circumference, and appetite in overweight subjects. Presented at the Scripps Center for Integrative Medicine's 6th Annual Natural Supplements Conference, San Diego, California. January 22-25.
Download Research PDF

Sinnott RA, Maddela RL, Nelson ED, et al. (2009) The modifying effects of a calcium-rich whey protein supplement (OsoLean® Powder) on weight loss and waist circumference in overweight subjects: a preliminary study. Open Nutraceuticals J 2:36-41.
Download Research PDF

Human Randomized, Double-Blind, Parallel Arm Study

Drs. Joy Frestedt and John Zenk (Minnesota Applied Research Center, Edina, MN), Michael Kuskowski (Geriatric Research Education and Clinical Center, Minneapolis, MN), and Loren Ward and Eric Bastian (Glanbia Research and Development Center, Twin Falls, ID) conducted this 12-week study on healthy subjects on a diet that reduced caloric intake by 500 calories/day. They showed that subjects who consumed a flavored and sweetened drink mix that contained the same peptide blend in OsoLean® powder lost significantly more body fat and lost less lean muscle mass when compared with those consuming an isocaloric beverage.*

Frestedt JL, Zenk JL, Kuskowski MA et al. (2008) A whey-protein supplement increases fat loss and spares lean muscle in obese subjects: a randomized human clinical study. Nutr Metab (Lond)  5(8):1-17.
Note: This article can also be accessed from PubMed.

Back to top

 
 


 

Mannatech, Incorporated.     Study was at least partially funded by Mannatech. In some cases, this means that Mannatech donated the product that was studied. In other cases, additional funding was provided.

 

* This statement has not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure or prevent any disease.

Windows Server 2008 Produktnyckel Windows 7 Chave windows 8 winkel Office 2013 winkel Windows 8 Chave