In the News

University of Memphis Scientists present Ambrotose AO^® supplement clinical study results at the American College of Sports Medicine’s (ACSM) Annual Meeting
June 9, 2010

Over 5,000 scientists, thought leaders and students convened in Baltimore, Maryland last week to share scientific progress in the rapidly growing field of sports medicine at the ACSM’s 57^th Annual Meeting. At this meeting, University of Memphis scientists presented data from a randomized, double‐blind, placebo‐controlled crossover trial, which showed that Ambrotose AO capsules significantly increased two measures of antioxidant capacity—oxygen radical absorbance capacity (ORAC) and Trolox Equivalent Antioxidant Capacity (TEAC)—in the blood of healthy men and women [1].*^† This third human clinical Ambrotose AO study further strengthens the evidence that 4 capsules/day of the product is safe and can improve the antioxidant capacity of human blood. The trial was lead by Dr. Richard J. Bloomer, Associate Professor and Director of the Cardiorespiratory/Metabolic Laboratory in the Department of Health and Sport Sciences at the University of Memphis, Memphis Tennessee and students Cameron G. McCarthy, Robert E. Canale and Kelsey H. Fisher‐Wellman. ACSM is the largest sports medicine and exercise science organization in the world, and ACSM members are the industry’s foremost health and fitness experts. The meeting was held June 1–5, 2010 in conjunction with the inaugural meeting of the World Congress on Exercise is Medicine™.
 

* This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
† Mannatech, Incorporated sponsored this study and provided the Ambrotose AO supplements used in this study.

BMC Complementary and Alternative Medicine publishes Ambrotose AO^® supplement clinical study
April 30, 2010

A study published in BMC Complementary and Alternative Medicine demonstrated that Ambrotose AO capsules significantly increased serum oxygen radical absorbance capacity (ORAC) in healthy adults by 36.6% [1].* ^† The five-week combined Phase 1 and 2 open label, forced titration dose response study provides additional evidence that Ambrotose AO^® capsules appear to be safe and are most effective at 4 capsules/day. The study was led by Professor Stephen Myers, PhD, BMed, ND, Director of the Australian Centre for Complementary Medicine Education and Research (ACCMER), a unique joint venture of the University of Queensland and Southern Cross University (SCU) and the NatMed-Research Unit, Research Cluster for Health and Wellbeing (NRU-RCHW), SCU, Lismore, AU. Co-authors included Dr. Lesley Stevenson (ACCM and the New Zealand Institute for Plant and Food Research Limited, Aukland, NZ); Drs. Phillip A. Cheras and Joan O’Connor (ACCM, NRU-RCHW); Dr. Lyndon Brooks (NRU-RCHW and Graduate Research College [GRC], SCU); Margaret Rolfe (GRC, SCU); Paul Connelan (ACCM, and the Centre for Phytochemistry and Pharmacology [CPP], SCU); and Dr. Carol Morris (CPP).
 

* This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
† Mannatech, Incorporated sponsored this study and provided the Ambrotose AO supplements used in this study.

A new Ambrotose ^® products study conducted by scientists from Ghent, Belgium, is published
April 7, 2010

Using state-of-the-art human gastrointestinal tract simulations and microbiological analyses, scientists from Ghent University and ProDigest (a company that specializes in gastrointestinal research) demonstrated that Ambrotose^® complex and Advanced Ambrotose^® powder exerted positive prebiotic effects (1).* ^† Both products exhibited good selective fermentability throughout the entire colon and positive and selective bifidogenic effects. They also demonstrated the possibility of enhancing species belonging to Bacteroidetes, a phylum recently associated with body weight management.* These findings by Drs. Massimo Marzorati and Sam Possemiers (U. of Ghent and ProDigest), A. Verhelst (ProDigest), Profs. Willy Verstraete and T. Van de Wiele (U. of Ghent) and Drs. Robert Sinnott and Gabriela Luta (Mannatech Incorporated) were electronically published online ahead of print in the peer‐reviewed International Journal of Food Microbiology
[http://dx.doi.org/10.1016/j.ijfoodmicro.2010.02.030].
 

† Mannatech, Incorporated funded this study and donated the Ambrotose products used in this study.
* This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Clinical study of Mannatech’s creatine-free EM•PACT^® sports drink published in the Journal of the International Society of Sports Nutrition
March 29, 2010

A randomized, double-blind, placebo-controlled, crossover trial investigating the effect of creatine-free EM•PACT sports drink on the aerobic performance of 29 healthy college students was published this week in the Journal of the International Society of Sports Nutrition [1] (http://www.jissn.com/content/7/1/12). In this study, funded by Mannatech, Dr. Allyn Byars and his colleagues showed that a single serving of creatine-free EM•PACT sports drink significantly improved subjects’ maximal oxygen consumption (VO2_max), time to exhaustion and percentage estimated non-protein fat substrate utilization. This study provides confirmation that the creatine-free EM•PACT product, which meets the compliance standards of various athletic organizations that regulate the use of nutritional supplements, provides benefits comparable to the original EM•PACT product with creatine [2],[3]. Dr. Byars is an Associate Professor of Kinesiology at Angelo State University in San Angelo, TX. Drs. Susan Keith and Warren Simpson (Angelo State University), Andy Mooneyhan (Arkansas State University in State University, Arkansas) and Dr. Mike Greenwood (Baylor University in Waco, Texas) were co-authors.

Mannatech Science Team Presents Poster at the 7^th Annual Scripps Natural Supplements Conference, January 21-24, 2010
January 30, 2010

The Scripps Center for Integrative Medicine‘s Annual Natural Supplements Conference brings together clinicians and experts in the field of integrative medicine to share the latest science about dietary supplementation and its impact on human health. For the sixth year in a row, Mannatech R&D scientists had a poster accepted for presentation at this prestigious event. The poster, “Immunomodulatory Polysaccharides: A Review of Human Oral Studies”, was presented by Dr. Erika Nelson, Research Scientist II, and Dr. Rolando Maddela, Global Clinical Research Manager at Mannatech.

Faculty this year included Dr. Wayne Jonas, President and CEO of the Samueli Institute, who delivered the keynote presentation: Meaning, Context and the Placebo Response. Other notable speakers included Dr. Mary Hardy, Medical Director at the Simms/Mann-UCLA Center for Integrative Oncology; Dr. Craig Hopp, Program Officer at the National Center for Complementary and Alternative Medicine at NIH; and Mark Blumenthal, Founder and Executive Director of the American Botanical Council.

To read more about Mannatech’s science, including posters presented at the Natural Supplements Conference, go to the Publications section of this site.

The Ambrotose ^® complex study conducted by scientists from Flinders University and the University of South Australia is published
December 31, 2009

In a 12-week, randomized, double-blind, placebo-controlled trial,^† healthy middle-aged adults who took Ambrotose^® complex performed significantly better on memory tasks and were overall more positive in their mood*(1). Dr. Talitha Best and Dr. Eva Kemps (School of Psychology, Flinders University, Adelaide, Australia) and Dr. Janet Bryan (School of Psychology, University of South Australia, Adelaide) published their findings in the January 2010 issue of Developmental Neuropsychology, a prestigious, peer-reviewed scientific journal.
 

† Mannatech, Incorporated donated the Ambrotose complex and placebo.
* This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Mannatech’s Educational Web site, MannatechScience.org, Receives a Web Health Merit Award
November 11, 2009

Surveys indicate that a majority of adults in the U.S. routinely search the Internet for health information.(1) It has been estimated that 80% of physicians get most health information from their colleagues, books and journals—those who try to access information online are typically not successful.

The Web Health Awards* (www.healthawards.com) is a program that recognizes the best web-based health-related content for consumers and professionals. The program, held twice a year, reviews web sites and bestows a seal of quality for those that provide reliable health information.

Mannatech’s educational web site, MannatechScience.org, has received a merit Web health award. The site provides peer-reviewed studies, product ingredient identity and safety information, product technical handouts, information about Mannatech’s Global Scientific Services department, and nutrition and supplementation information.

This seal of quality should remind consumers that a panel of international health information and Internet experts have reviewed the site and approved it for accuracy, success in reaching its targeted audience and overall quality.
 

*The Web Health Awards program is organized by the Health Information Resource Center (HIRC), a national clearinghouse for consumer health information programs and materials. This web-based health awards program is an extension of the HIRC's 16-year old National Health Information Awards (NHIA), the largest program of its kind in the United States. There were nearly 1,000 entries in last year's National Health Information Awards from hundreds of organizations.

Mannatech Presents Science at Glycobiology and Medicine Symposium
October 8, 2009

Two posters about Mannatech’s Ambrotose^® technology were presented at the 9th Annual Jenner Glycobiology and Medicine Symposium, held in Brussels, Belgium, September 13‒15, 2009. The first poster, presented by Dr. Robert A. Sinnott, Mannatech’s Chief Science Officer, presented preclinical data indicating that orally administered Advanced Ambrotose^® powder has a beneficial effect on gene expression in the colon of healthy mice. The animal study was conducted by Eurofins/Product Safety Laboratories in New Jersey, and the gene expression analysis was conducted by scientists at University of Texas Southwestern Medical Center at Dallas. Mannatech’s R&D group funded and managed the project and compiled the data.

Researchers at St. George's University of London presented the second poster, an open-label human study which showed that Advanced Ambrotose^® powder supplementation affects the N-glycosylation profile in blood*.

Over 100 participants— from major research groups in the area of glycobiology and medicine, from Europe, Asia and the United States—were in attendance. The meeting was organized by the Royal Society of Medicine (U.K.) in association with the Rega Institute for Medical Research at the Catholic University of Leuven, Belgium.

*study was funded by an academic research grant from Mannatech, Incorporated

BounceBack™ capsules study conducted by scientists from Medicus Research LLC and the University of California, Los Angeles (UCLA) is published
June 5, 2009

BounceBack™ capsules were able to significantly reduce standardized measures of pain and tenderness at several post-eccentric exercise time points in comparison to placebo (1). Jay Udani, MD (Medicus Research LLC, Northridge, California and UCLA Geffen School of Medicine), and Drs. Betsy Singh and Vijay Singh (Medicus Research LLC) published the randomized, double-blind, placebo-controlled crossover trial in the Journal of the International Society of Sports Nutrition.

Mannatech’s Chief Science Officer to serve as vice chairman of the Council for Responsible Nutrition’s Senior Scientific Advisory Council (SSAC)
April 27, 2009

The Council for Responsible Nutrition (CRN), a Washington, D.C.-based trade association that represents dietary supplement manufacturers and ingredient suppliers, has selected Dr. Robert Sinnott, Mannatech, Incorporated’s Chief Science Officer, to serve as vice chairman of their Senior Scientific Advisory Council (SSAC). The SSAC is made up of the highest ranking science officers of member companies who have volunteered to advise the CRN staff and the association's board of directors on major scientific issues.

"It's an honor to be selected by the CRN board chairman, and I look forward to working with the SSAC and other industry leaders as we continue to take a proactive approach toward advancing the wellness industry," said Dr. Sinnott. "Serving in this role is a good opportunity to further influence industry issues, such as validating safety, quality and beneficial effects of dietary supplements and functional foods. Active members of the SSAC represent many decades of scientific knowledge. It will be a great privilege to work with them and the scientific leadership of the CRN to address scientific and economic issues facing us at a national level."

In addition to complying with a host of federal and state regulations governing dietary supplements, CRN members also agree to adhere to CRN's Code of Ethics and to voluntary guidelines for product manufacturing and marketing. Dr. Sinnott also represents Mannatech on CRN's board of directors. Mannatech has been a member of CRN since 2002.

Scientists from Howard University publish Ambrotose^® complex study in the journal Perceptual & Motor Skills
April 16, 2009

Drs. Atiya N. Stancil and Leslie H. Hicks, both of Howard University in Washington, D.C., published a randomized, double-blind, placebo-controlled study investigating the impact of Ambrotose complex on the brain function of 62 healthy young adults. The study showed that a single, one-tablespoon serving of Ambrotose complex significantly improved visual discrimination and working memory. Mannatech, Incorporated donated the product used in this study, which was funded by Kraft Foods, Inc. (1).

Previous double-blind, placebo-controlled clinical trials have demonstrated that ingestion of Ambrotose complex can enhance brain waves associated with attention or alertness (2), enhance concentration and improve mental reaction time (3), and improve memory (4).

NSF E-News Supplement Features Mannatech Products’ Case Study
April 1, 2009

Unlike other supplement certification programs, NSF International conducts annual audits and periodically retests each dietary supplement product to ensure continued compliance against the toughest testing standard in existence today. Mannatech, which has eight NSF Certified products, was featured in NSF’s April 2009 E-News Supplement.
 

To read the case study:
http://www.nsf.org/business/newsroom/articles/0903_n3_MannatechCaseStudy.asp

To read the April 2009 NSF E-News Supplement:
http://www.nsf.org/media/enews/n3_0903.html

For more information about the NSF Certification program:
http://www.nsf.org/business/newsroom/pdf/DS-prod_cert.pdf

Mannatech’s OsoLean™ powder study published in the Open Nutraceuticals Journal
March 16, 2009

A clinical study of OsoLean powder funded by Mannatech was published this week in the Open Nutraceuticals Journal. This preliminary, open-label, 8-week study of 112 overweight adults demonstrated that daily intake of OsoLean powder appeared to reduce appetite, support weight loss and reduce waist circumference. The study was conducted by Mannatech scientists in collaboration with researchers at the University of North Texas Health Science Center in Fort Worth, TX. In a related 12-week double-blind, placebo-controlled study published in 2008, consumption of the same peptide blend in OsoLean powder in a flavored, sweetened beverage, in conjunction with a 500-calorie reduced diet, helped to enhance fat loss and retain lean muscle mass when compared to control subjects consuming a placebo in addition to dieting. To read more about Mannatech’s science, including these studies, go to the Publications section of this site.

Sinnott RA, Maddela RL, Nelson ED, Bae S, Singh KP, Anderson JA. The modifying effects of a calcium-rich whey protein supplement (OsoLean™ Powder) on weight loss and waist circumference in overweight subjects: a preliminary study. Open Nutraceuticals J 2009; 2:36-41.

Frestedt JL, Zenk JL, Kuskowski MA, Ward LS, Bastian ED. A whey-protein supplement increases fat loss and spares lean muscle in obese subjects: a randomized human clinical study. Nutr Metab (Lond) 2008; 5:8.

Mannatech Science Team Attends Natural Supplements Conference
January 26, 2009

Based in La Jolla, California, the Scripps Center for Integrative Medicine is devoted to developing personalized programs for the unique needs of their patients by “blending traditional medicine with evidence-based complementary therapies and advanced technology”. The Center also hosts numerous conferences devoted to providing Continuing Medical Education to healthcare professionals, including their annual Natural Supplements Conference. This conference brings together experts in the field of integrative medicine to present science-based information about dietary supplementation. Scientists are also invited to present the results of their recent research at the Conference’s poster competition. Mannatech R&D scientists presented four scientific posters at the 6th Annual Natural Supplements: An Evidence-Based Update on January 23—25, 2009. Three posters were devoted to Ambrotose^® product technology and the fourth presented the results of open-label human study on Mannatech’s new supplement designed to target fat loss, OsoLean™ powder. Dr. Allyn Byars, Associate Professor of Physical Therapy at Angelo State University, San Angelo, TX, also presented a poster about Mannatech’s pre-exercise supplement, EMPACT™ sports drink.

Faculty this year included Dr. Mary Ruggie, Professor of Public Policy at Harvard University’s Kennedy School of Government, who delivered the keynote presentation: Dietary Supplements, Integrative Medicine, and the New Direction in Health Care. Other notable speakers included Dr. Paul Coates, Director of NIH’s Office of Dietary Supplements, Dr. Paula Gardiner, Assistant Professor at Boston Medical Center, and Tieraona Low Dog, Director of the Fellowship at the Arizona Center for Integrative Medicine.

Mannatech has presented posters at the last four Annual Natural Supplements Conferences and Mannatech-funded research won 1st and 2nd place awards for Basic Science in 2006. To read more about Manntech’s science, including posters presented at the Natural Supplements Conference, go to the Peer Reviewed Science section of this site.