Product Details

Novel bilayer tablet that contains both white and red fermented Panax ginseng powders

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Ingredients

Functional

  • Aloe vera extract (inner leaf gel powder)

     Aloe vera extract inner leaf gel powder includes Manapol®, a polysaccharide found in aloe vera gel. A unique ingredient exclusive to Mannatech, Incorporated, Manapol is extracted from fresh, washed and filtered gel by a specialized extraction method that yields insoluble fibers and stabilized, high molecular weight (MW) soluble fibers rich in long-chain mannose sugars—beta-(1-4)-acetylated polymannans. Many attribute the benefits of topically and orally-applied aloe vera gel to its polymannan content. The MW of over 20% of Manapol is >800,000. It also contains the monosaccharide sugars glucuronic acid, glucose, galacturonic acid, xylose, galactose, glucosamine, fucose, rhamnose and arabinose, and small amounts of protein, calcium, potassium and sulfate 1,2,3.

    Expand References

    References

    1. Luta G, McAnalley B. Aloe vera: chemical composition and methods used to determine its presence in commercial products. GlycoScience & Nutrition 2005;6:1-12.
    2. Duncan, C., Ramberg, J., and Sinnott, R. Striking differences in Aloe vera gel carbohydrate composition, molecular weight and particle size distributions following processing will not be addressed by dietary supplement GMPs. Poster Presentation at the 5th Annual Natural Supplements Conference, January 17-20, 2008, Scripps Center for Integrative Medicine, San Diego, California.
    3. Luta G, Duncan C, Sinnott R. Chemical characterization of polysaccharide-rich ingredients from Aloe vera, Larix laricina and Larix occidentalis, and Undaria pinnatifida. Presented at the 6th Annual Natural Supplements Conference, January 22-25, 2009, Scripps Center for Integrative Medicine, San Diego, California.
  • Cichorium intybus root extract

    Cichorium intybus (chicory) is an herbaceous flowering plant used for food and medicinal purposes throughout Europe, North America and the Middle East. The leaves are used as a salad vegetable and the roots, when roasted and ground, can be added to coffee for a darker color and a more bitter taste 1. The roots are rich in short-chain fructo-oligosaccharides, prebiotic fibers that can simulate the growth of healthful bacteria in the gut, including Bifidobacteria spp. 2,3,4.

    Expand References

    References

    1. Grieve M. A Modern Herbal. NY, NY: Dover Publications, Inc., 1971.
    2. Bornet FR, Brouns F, Tashiro Y, Duvillier V. Nutritional aspects of short-chain fructooligosaccharides: natural occurrence, chemistry, physiology and health implications. Dig.Liver Dis. 2002;34 Suppl 2:S111-S120.
    3. de Wiele TV, Boon N, Possemiers S, Jacobs H, Verstraete W. Prebiotic effects of chicory inulin in the simulator of the human intestinal microbial ecosystem. FEMS Microbiol Ecol 2004;51:143-53.
    4. Flamm G, Glinsmann W, Kritchevsky D, Prosky L, Roberfroid M. Inulin and oligofructose as dietary fiber: a review of the evidence. Crit Rev Food Sci Nutr 2001;41:353-62.
  • D-ribose

    Ribose is a five-carbon sugar that is essential for cellular metabolism. Produced by the human body, it is used for the production of nucleic acids (RNA and DNA) and the energy “currency” for all life, adenosine triphosphate (ATP) 1.

     

    Expand References

    References

    1. Ensminger AH, Ensminger ME, Konlande JE, Robson JRK. The Concise Encyclopedia of Foods and Nutrition. Boca Raton, Florida: CRC Press, 1995.
  • Fermented red ginseng root extract

    Native to mountain forests of East Asia, Panax ginseng  (from “Jen shen”, or “man herb”) is now cultivated in China, Japan, Russia and Korea. For over two thousand years, the root of P. ginseng   has been used as a tonic, energizer, to help aid concentration, to help reduce anxiety and emotional instability and as a restorative to promote health and longevity 1,2,3. It has a long history of traditional use in China for improving memory 4, and has been used traditionally by many cultures as an “adaptogen” (a substance that is able to help the body adapt to environmental or internal stresses without altering normal physiology) 3,5.

    P. ginseng roots are prepared either by steaming and then drying to produce red ginseng or by sun-drying to produce white ginseng. The roots contain ginsenosides (glycosylated triterpenoid saponins), a volatile oil, sterols (including beta-sitosterol), starch, polysaccharides, caffeine, theophylline, theobromine, vitamins (B1, B2, B12, nicotinic acid, pantothenic acid, biotin), choline, fats, and minerals (zinc, copper, manganese, calcium, and iron). Panax spp. are best known, however, for their over 150 ginsenosides, which appear to be responsible for the root’s benefits for humans 6,7.

    Research indicates that ginsenosides are poorly absorbed, and there is some evidence that ginsenoside metabolites formed by intestinal bacteria after oral intake may account for the root’s health benefits. It has also been demonstrated that individual responses to ginseng supplements can be affected by specific gut flora populations 8.

    To enhance bioavailability of ginsenosides, fermented red ginseng preparations containing ginsenoside metabolites have been developed. These products are pre-digested with enzymes, bacteria or fungi. Red ginseng includes the following ginsenosides: Rg1, Rf, Re, Rd, Rb2, Rc, Rb1 9. The major ginsenoside, Rb1 is metabolized to compound K by intestinal microflora, which has received particular attention as a biologically important ginsenoside metabolite 10.

    Research indicates that fermented ginseng products may be superior to standard non-fermented ginsengs 9,11,12,13,14. When compared with oral intake of standard red ginseng, intake of fermented red ginseng by human subjects results in higher levels of compound K in the blood 11,15. Studies comparing red ginseng with fermented red ginseng employing in vitro 8,16,17 animal 8 and human bioavailability 18,19 studies indicate that ginsenosides from fermented red ginseng may be more bioavailable than those from standard red ginseng.

    In human oral studies, intake of Panax ginseng has been shown to support healthy brain and cognitive function, mental alertness and focus 20,21,22. Improvements in mood, 23 quality of life 24,25, overall wellness 26 and healthy immune system function 27,28 have also been documented.

    The German Commission E reports that P. ginseng has no known side effects, contraindications or interactions with other drugs 2. A systematic review of adverse effects and drug interactions was published for Panax ginseng . The authors found that data from clinical trials suggest that the incidence of adverse events with ginseng preparations is similar to that of placebo 29. Animal toxicity studies found ginseng to be very safe, with no teratogenicity or mutagenicity 30.

    Expand References

    References

    1. Duke JA. GINSENG: A Concise Handbook. Algonac, Mi.: Reference Publications, Inc., 1989.
    2. The Complete German Commission E. Monographs: Therapeutic Guide to Herbal Medicines. Boston, Mass.: American Botanical Council in cooperation with Integrative Medicine Communications, 1998.
    3. Radad K, Gille G, Liu L, Rausch WD. J Pharmacol Sci 2006;100:175-86.
    4. May BH, Feng M, Zhou IW et al. J Altern Complement Med 2016;22:695-705.
    5. Lee SM, Bae BS, Park HW et al. Characterization of Korean Red Ginseng (Panax ginseng Meyer): History, preparation method, and chemical composition. J Ginseng Res 2015;39:384-91.
    6. Senchina DS, Shah NB, Doty DM, Sanderson CR, Hallam JE. Herbal supplements and athlete immune function--what's proven, disproven, and unproven? Exerc.Immunol Rev 2009;15:66-106.
    7. Bruneton J. Pharmacognosy, Phytochemistry, Medicinal Plants. Paris, France: Lavoisier Publishing, 1995.
    8. Lee HJ, Jung EY, Lee H-S et al. Bioavailability of fermented korean red ginseng. J Fod Sci Nutr 2009;14:201-7.
    9. Kim BG, Shin KS, Yoon TJ et al. Fermentation of Korean red ginseng by Lactobacillus plantarum M-2 and its immunological activities. Appl Biochem Biotechnol 2011;165:1107-19.
    10. Yim JS, Kim YS, Moon SK et al. Metabolic activities of ginsenoside Rb1, baicalin, glycyrrhizin and geniposide to their bioactive compounds by human intestinal microflora. Biol Pharm Bull 2004;27:1580-3.
    11. Choi ID, Ryu JH, Lee DE et al. Enhanced Absorption Study of Ginsenoside Compound K (20-O-beta-(D-Glucopyranosyl)-20(S)-protopanaxadiol) after Oral Administration of Fermented Red Ginseng Extract (HYFRG) in Healthy Korean Volunteers and Rats. Evid Based Complement Alternat.Med 2016;2016:3908142.
    12. Kim KA, Jung IH, Park SH, Ahn YT, Huh CS, Kim DH. Comparative analysis of the gut microbiota in people with different levels of ginsenoside Rb1 degradation to compound K. PLoS ONE 2013;8:e62409.
    13. Kim NH, Kim KY, Jeong HJ, Kim HM. Antidepressant-like effect of altered Korean red ginseng in mice. Behav Med. 2011;37:42-6.
    14. Kho MC, Lee YJ, Park JH et al. Fermented Red Ginseng Potentiates Improvement of Metabolic Dysfunction in Metabolic Syndrome Rat Models. Nutrients. 2016;8.
    15. Jin H, Seo JH, Uhm YK, Jung CY, Lee SK, Yim SV. Pharmacokinetic comparison of ginsenoside metabolite IH-901 from fermented and non-fermented ginseng in healthy Korean volunteers. J Ethnopharmacol. 2012;139:664-7.
    16. Ryu JS, Lee HJ, Bae SH et al. The bioavailability of red ginseng extract fermented by Phellinus linteus. J Ginseng.Res 2013;37:108-16.
    17. Kim B-G, Choi S-Y, Kim M-R, Suh H J, Park HJ. Changes of ginsenosides in Korean red ginseng (Panax ginseng) fermented by Lactobacillus plantarum M1. Process Biochem 2010;45:1319-24.
    18. Kim JS, Kim Y, Han SH et al. Development and validation of an LC-MS/MS method for determination of compound K in human plasma and clinical application. J Ginseng.Res 2013;37:135-41.
    19. Jin H, Seo JH, Uhm YK, Jung CY, Lee SK, Yim SV. Pharmacokinetic comparison of ginsenoside metabolite IH-901 from fermented and non-fermented ginseng in healthy Korean volunteers. J Ethnopharmacol 2012;139:664-7.
    20. Reay JL, Kennedy DO, Scholey AB. Single doses of Panax ginseng (G115) reduce blood glucose levels and improve cognitive performance during sustained mental activity. J Psychopharmacol. 2005;19:357-65.
    21. Reay JL, Kennedy DO, Scholey AB. Effects of Panax ginseng, consumed with and without glucose, on blood glucose levels and cognitive performance during sustained 'mentally demanding' tasks. J Psychopharmacol. 2006;20:771-81.
    22. D'Angelo L, Grimaldi R, Caravaggi M et al. A double-blind, placebo-controlled clinical study on the effect of a standardized ginseng extract on psychomotor performance in healthy volunteers. J Ethnopharmacol. 1986;16:15-22.
    23. Reay JL, Scholey AB, Kennedy DO. Panax ginseng (G115) improves aspects of working memory performance and subjective ratings of calmness in healthy young adults. Hum Psychopharmacol. 2010;25:462-71.
    24. Coleman CI, Hebert JH, Reddy P. The effects of Panax ginseng on quality of life. J Clin Pharm Ther 2003;28:5-15.
    25. Ellis JM, Reddy P. Effects of Panax ginseng on quality of life. Ann Pharmacother. 2002;36:375-9.
    26. Yi SW, Sull JW, Hong JS, Linton JA, Ohrr H. Association between ginseng intake and mortality: Kangwha cohort study. J Altern Complement Med 2009;15:921-8.
    27. Scaglione F, Ferrara F, Dugnani S, Falchi M, Santoro G, Fraschini F. Immunomodulatory effects of two extracts of Panax ginseng C.A. Meyer. Drugs Exp Clin Res 1990;16:537-42.
    28. Scaglione F, Weiser K, Allesandria M. Effects of the Standardised Ginseng Extract G115(Reg.) in Patients with Chronic Bronchitis: A Nonblinded, Randomised, Comparative Pilot Study. Clin Drug Invest (NZ) 2001;21:41-5.
    29. Coon JT, Ernst E. Panax ginseng: a systematic review of adverse effects and drug interactions. Drug Saf 2002;25:323-44.
    30. Bucci LR. Selected herbals and human exercise performance. Am J Clin Nutr 2000;72:624S-36S.
  • Fermented white ginseng root extract

    Native to mountain forests of East Asia, Panax ginseng  (from “Jen shen”, or “man herb”) is now cultivated in China, Japan, Russia and Korea. For over two thousand years, the root of P. ginseng   has been used as a tonic, energizer, to help aid concentration, to help reduce anxiety and emotional instability and as a restorative to promote health and longevity 1,2,3. It has a long history of traditional use in China for improving memory 4, and has been used traditionally by many cultures as an “adaptogen” (a substance that is able to help the body adapt to environmental or internal stresses without altering normal physiology) 3,5.

    P. ginseng roots are prepared either by steaming and then drying to produce red ginseng or by sun-drying, to produce white ginseng. The roots contain ginsenosides (glycosylated triterpenoid saponins), a volatile oil, sterols (including beta-sitosterol), starch, polysaccharides, caffeine, theophylline, theobromine, vitamins (B1, B2, B12, nicotinic acid, pantothenic acid, biotin), choline, fats, and minerals (zinc, copper, manganese, calcium, and iron). Panax spp. are best known, however, for their over 150 ginsenosides, which appear to be responsible for the root’s benefits for humans 6,7.

    Research indicates that ginsenosides are poorly absorbed, and there is some evidence that ginsenoside metabolites formed by intestinal bacteria after oral intake may account for the root’s health benefits. It has also been demonstrated that individual responses to ginseng supplements can be affected by specific gut flora populations 8.

    Fermented ginseng products may be superior to standard non-fermented ginsengs 9,10,11,12,13. In human oral studies, intake of P. ginseng has been shown to support healthy brain and cognitive function, mental alertness and focus 14,15,16. Improvements in mood, 17 quality of life 18,19, overall wellness 20 and healthy immune system function 20,22 have also been documented.

    The German Commission E reports that P. ginseng has no known side effects, contraindications or interactions with other drugs 2. A systematic review of adverse effects and drug interactions was published for Panax ginseng . The authors found that data from clinical trials suggest that the incidence of adverse events with ginseng preparations is similar to that of placebo 23. Animal toxicity studies found ginseng to be very safe, with no teratogenicity or mutagenicity 24.

    Expand References

    References

    1. Duke JA. GINSENG: A Concise Handbook. Algonac, Mi.: Reference Publications, Inc., 1989.
    2. The Complete German Commission E. Monographs: Therapeutic Guide to Herbal Medicines. Boston, Mass.: American Botanical Council in cooperation with Integrative Medicine Communications, 1998.
    3. Radad K, Gille G, Liu L, Rausch WD. J Pharmacol Sci 2006;100:175-86.
    4. May BH, Feng M, Zhou IW et al. J Altern Complement Med 2016;22:695-705.
    5. Lee SM, Bae BS, Park HW et al. Characterization of Korean Red Ginseng (Panax ginseng Meyer): History, preparation method, and chemical composition. J Ginseng Res 2015;39:384-91.
    6. Senchina DS, Shah NB, Doty DM, Sanderson CR, Hallam JE. Herbal supplements and athlete immune function--what's proven, disproven, and unproven? Exerc.Immunol Rev 2009;15:66-106.
    7. Bruneton J. Pharmacognosy, Phytochemistry, Medicinal Plants. Paris, France: Lavoisier Publishing, 1995.
    8. Lee HJ, Jung EY, Lee H-S et al. Bioavailability of fermented korean red ginseng. J Fod Sci Nutr 2009;14:201-7.
    9. Choi ID, Ryu JH, Lee DE et al. Enhanced Absorption Study of Ginsenoside Compound K (20-O-beta-(D-Glucopyranosyl)-20(S)-protopanaxadiol) after Oral Administration of Fermented Red Ginseng Extract (HYFRG) in Healthy Korean Volunteers and Rats. Evid Based Complement Alternat.Med 2016;2016:3908142.
    10. Kim KA, Jung IH, Park SH, Ahn YT, Huh CS, Kim DH. Comparative analysis of the gut microbiota in people with different levels of ginsenoside Rb1 degradation to compound K. PLoS ONE 2013;8:e62409.
    11. Kim BG, Shin KS, Yoon TJ et al. Fermentation of Korean red ginseng by Lactobacillus plantarum M-2 and its immunological activities. Appl Biochem Biotechnol 2011;165:1107-19.
    12. Kim NH, Kim KY, Jeong HJ, Kim HM. Antidepressant-like effect of altered Korean red ginseng in mice. Behav Med. 2011;37:42-6.
    13. Reay JL, Kennedy DO, Scholey AB. Single doses of Panax ginseng (G115) reduce blood glucose levels and improve cognitive performance during sustained mental activity. J Psychopharmacol. 2005;19:357-65.
    14. Reay JL, Kennedy DO, Scholey AB. Effects of Panax ginseng, consumed with and without glucose, on blood glucose levels and cognitive performance during sustained 'mentally demanding' tasks. J Psychopharmacol. 2006;20:771-81.
    15. Kho MC, Lee YJ, Park JH et al. Fermented Red Ginseng Potentiates Improvement of Metabolic Dysfunction in Metabolic Syndrome Rat Models. Nutrients. 2016;8.
    16. D'Angelo L, Grimaldi R, Caravaggi M et al. A double-blind, placebo-controlled clinical study on the effect of a standardized ginseng extract on psychomotor performance in healthy volunteers. J Ethnopharmacol. 1986;16:15-22.
    17. Reay JL, Scholey AB, Kennedy DO. Panax ginseng (G115) improves aspects of working memory performance and subjective ratings of calmness in healthy young adults. Hum Psychopharmacol. 2010;25:462-71.
    18. Coleman CI, Hebert JH, Reddy P. The effects of Panax ginseng on quality of life. J Clin Pharm Ther 2003;28:5-15.
    19. Ellis JM, Reddy P. Effects of Panax ginseng on quality of life. Ann Pharmacother. 2002;36:375-9.
    20. Yi SW, Sull JW, Hong JS, Linton JA, Ohrr H. Association between ginseng intake and mortality: Kangwha cohort study. J Altern Complement Med 2009;15:921-8.
    21. Scaglione F, Ferrara F, Dugnani S, Falchi M, Santoro G, Fraschini F. Immunomodulatory effects of two extracts of Panax ginseng C.A. Meyer. Drugs Exp Clin Res 1990;16:537-42.
    22. Scaglione F, Weiser K, Allesandria M. Effects of the Standardised Ginseng Extract G115(Reg.) in Patients with Chronic Bronchitis: A Nonblinded, Randomised, Comparative Pilot Study. Clin Drug Invest (NZ) 2001;21:41-5.
    23. Coon JT, Ernst E. Panax ginseng: a systematic review of adverse effects and drug interactions. Drug Saf 2002;25:323-44.
    24. Bucci LR. Selected herbals and human exercise performance. Am J Clin Nutr 2000;72:624S-36S.
  • Glycerin

    Glycerin is a chemical compound used in skin care products and cosmetics as a humectant, that is, a skin conditioning agent that increases water content of the top layers of the skin by drawing moisture from the surrounding air. Glycerin also acts as a lubricant on the skin surface, which gives the skin a soft and smooth appearance 1.

    In oral solutions, glycerin is used as a solvent, sweetening agent, antimicrobial preservative, and viscosity-increasing agent. It can also be used in film coatings for tablets.1.

    Glycerin is included in the U.S. Food and Drug Administration (FDA) Inactive Ingredients Guide as safe to use in the amounts present in our products.

    Expand References

    References

    1. Handbook of Pharmaceutical Excipients. Washington, DC: Pharmaceutical Press and American Pharmacists Assn, 2006.
  • Vitamin B12 (from baker's yeast)

    Vitamin B12 is an essential water-soluble vitamin that is commonly found in a variety of animal foods such as fish, shellfish, meat and dairy products. Synthetic vitamin B12 is frequently used in combination with other B vitamins in vitamin B complex formulations and added to supplements and fortified foods such as cereals. An adequate supply of vitamin B12 is essential to maintain healthy nerve cell and red blood cell function, as well as for folate utilization. The average fractional absorption of vitamin B12 from food by healthy individuals is approximately 50 percent, while synthetic vitamin B12 has increased bioavailability 1.
    No adverse effects have been associated with vitamin B12 intake from food or supplements in healthy individuals 1. The U.S. Food and Drug Administration (FDA) has established a Reference Daily Intake (RDI) of 6 μg vitamin B12 for adults and children 4 or more years of age (21CFR101.9). RDIs are a set of dietary references for essential vitamins and minerals that are considered amounts sufficient to meet the daily requirements of healthy individuals. RDIs serve as the basis for calculating the percent daily value (%DV) amounts found on dietary supplement and food labels.
    Baker’s yeast, Saccharomyces cerevisiae, also known as brewer’s yeast, is a yeast often used for baking or brewing. It is an excellent source of the essential B vitamins, including folic acid, niacin, biotin, pantothenic acid, riboflavin, thiamin and vitamin B6 2.

    Expand References

    References

    1. Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, D.C.: National Academy Press, 2000.
    2. Natural Medicines. Comprehensive Database. Therapeutic Research Faculty, 2003.
  • Zinc (as zinc gluconate)

    Zinc is an essential trace element necessary for the functioning of approximately 100 different enzymes in the body. It plays a vital role in many biological processes, such as the maintenance of protein structures, the regulation of gene expression and the metabolism of hormones. Zinc is abundant in red meats, certain seafood and whole grains 1.

    Zinc is regarded as relatively safe and generally well tolerated when taken as a supplement at recommended amounts. The U.S. Food and Drug Administration (FDA) has established a Reference Daily Intake (RDI) of 15 mg zinc for adults and children 4 or more years of age (21CFR101.9). RDIs are a set of dietary references for essential vitamins and minerals that are considered amounts sufficient to meet the daily requirements of healthy individuals. RDIs serve as the basis for calculating the percent daily value (%DV) amounts found on dietary supplement and food labels.

    Zinc gluconate is a form of chelated zinc in which a zinc ion is bound to gluconic acid. It is used as a source of the essential mineral zinc in dietary supplements, and generally recognized as safe (GRAS) by the FDA (21 CFR 182.8988).

     

    Expand References

    References

    1. Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, D.C.: National Academy Press, 2002.

Formulation

  • Beet root juice powder

    Beets, the root of the plant Beta vulgaris, have been consumed since medieval times in Europe. Today, beets are mainly cultivated in the U.S. and Europe 1. The deep purple-red color of beets is due to the presence of pigments known as betacyanins, which can be used as natural red food colorants. Betacyanins also possess antioxidant activities 2.

    Expand References

    References

    1. Ensminger AH, Ensminger ME, Konlande JE, Robson JRK. The Concise Encyclopedia of Foods and Nutrition. Boca Raton, Florida: CRC Press, 1995.
    2. Esatbeyoglu T, Wagner AE, Schini-Kerth VB, Rimbach G. Betanin--a food colorant with biological activity. Mol Nutr Food Res 2015;59:36-47.
  • Carboxymethylcellulose calcium

    Carboxymethylcellulose calcium is a calcium salt of a cellulose derivative that is primarily used in pharmaceutical and dietary supplement products as binder/diluent or disintegrant in tablets. It is considered to be safe, non-toxic and non-irritating 1.

    Expand References

    References

    1. Handbook of Pharmaceutical Excipients. Chicago, Il: Pharmaceutical Press, 2009.
  • Hydroxypropyl methylcellulose

    Hydroxypropyl methylcellulose (HPMC), also known as hypromellose, is a derivative of cellulose. In oral products, HPMC is primarily used as a binder and for encapsulation as an alternative to animal-derived gelatin. In foods, it is used as a thickener and to stabilize oil-in-water mixtures 1. Hydroxypropyl methylcellulose is an approved food additive by the U.S. Food and Drug Administration (FDA) (21CFR172.874).

    This ingredient can also be found in the following products:

    Expand References

    References

    1. Handbook of Pharmaceutical Excipients. Washington, DC: Pharmaceutical Press and American Pharmacists Assn, 2006.
  • Isomalt

    Isomalt is a sugar alcohol used in pharmaceutical and dietary supplement products as a coating agent, granulation aid, sweetener, or as a tablet/capsule diluent. Dietary isomalt, largely fermented in the large intestine, does not increase blood glucose levels 1.

    Expand References

    References

    1. Handbook of Pharmaceutical Excipients. Chicago, Il: Pharmaceutical Press, 2009.
  • Microcrystalline cellulose

    Microcrystalline cellulose (MC) is a purified plant fiber that is widely used in food products and in dietary supplement tablets to: 1) bind ingredients together, or 2) help the tablet disintegrate properly.

    Following ingestion, MC is not absorbed by the human body. Because it is not absorbed, it has little potential for toxicity. Consumption of large quantities of cellulose may have a laxative effect, but this is unlikely to be a problem for individuals consuming the small amounts included in dietary supplement tablets 1.

    Expand References

    References

    1. Handbook of Pharmaceutical Excipients. Washington, DC: Pharmaceutical Press and American Pharmacists Assn, 2006.
  • Silicon dioxide

    Silicon dioxide, also known as silica, is added to capsule and tablet formulations to reduce clumping 1. Silica is found in many foods, particularly whole grains (oats and barley), sugar beets, sugar cane, soybeans, turnips, green beans 2. The average intake of silica in adults is 14-21 mg/day 3. The bioavailability of silicate additives is low 4. Silica that occurs in food and water has not been shown to cause any adverse effects 3.

    Expand References

    References

    1. The Merck Index. Whitehouse Station, NJ: Merck & Co., 2006.
    2. Nutritional Biochemistry and Metabolism. New York, New York: Elsevier, 1991.
    3. Natural Medicines: Comprehensive Database. Stockton, CA: Therapeutic Research Faculty, 2000.
    4. Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, D.C.: National Academy Press, 2002.
  • Stearic acid

    Stearic acid is a naturally occurring fatty acid that is found in animal and vegetable fats. In dietary supplements, it is typically a combination of stearic and palmitic acids. Stearic acid is used as a lubricantin capsules and tablets and is also used widely in cosmetics and food products 1. It is used in topical formulations to assist in mixing ingredients and to stabilize oil-in-water mixtures 2.

    Stearic acid is approved by the U.S. Food and Drug Administration (FDA) as generally recognized as safe (GRAS) (21CFR184.1090) and is generally regarded as a nontoxic and nonirritating material 1. It is also included in the U.S. FDA Inactive Ingredients Guide as safe to use in the amounts present in our products 3.

    Expand References

    References

    1. Handbook of Pharmaceutical Excipients. Gurnee, IL: Pharmaceutical Press, 2006.
    2. International Cosmetic Ingredient Dictionary and Handbook. Washington, D.C.: The Cosmetic, Toiletry and Fragrance Association, 2006.
    3. FDA Inactive Ingredients Guide. http://www.accessdata.fda.gov/scripts/cder/iig/index.cfm. 2007.

Product Claims

Products

U.S. GINMAX tablets

Product Numbers

18301: 120 U.S. GINMAX tablets

Country

United States

Effective

February 2017

Supersedes

NA
  • Quality and Safety
    • Low glycemic
    • Gluten-free
    • Free from dairy
    • Free from soy
    • Free from artificial colors
    • Free from artificial flavors
    • Free from MSG
  • Benefits
    • Excellent source of vitamin B12
    • For over two thousand years, the root of Panax ginseng has been used as a tonic, energizer, to help aid concentration, to help reduce anxiety and emotional instability and as a restorative to promote health and longevity
    • Panax ginseng has been used traditionally in Asia for thousands of years, particularly for its invigorating, anti-aging benefits
    • Panax ginseng has a long history of traditional use in China for improving memory
    • Panax has been used traditionally as an adaptogen, and to help restore [homeostasis/equilibrium of the body
    • Supports healthy brain and cognitive function
    • Promotes mental alertness and focus
    • Supports all-natural mental energy
    • Promotes improved cognitive performance
    • Supports mood
    • Supports healthy memory function
    • Supports all-natural (physical energy/vitality)
    • Popular supplement among athletes
    • May improve quality of life
    • Antioxidant
    • Supports healthy aging
    • Supports wellness
    • May support healthy immune system function
    • Fresh ginseng is easily degraded at room temperature, so consumers should prefer carefully dried products
    • Fermented ginseng products may be superior to standard ginsengs
    • Includes chicory to help prime the fermentation of ginseng
    • A novel bilayer tablet that contains a fast acting specialized fermented white Korean Ginseng in one layer.  The second layer contains a very high quality fermented red ginseng.  The special fermented white ginseng is intended to provide quick results while the ginsenosides in the fermented red ginseng are being metabolized, to help provide a sustained effect.
    • Red ginseng ginsenosides can fermented by bacteria, including Lactobacillus plantarum, a probiotic in GI-Probalance, to include more potent ginsenoside metabolites
    • Conversion of ginsenosides into their active metabolites can be highly variable and appears to depend on composition of gut microflora. The intestinal bacterial metabolism of ginseng, particularly a key ginsenoside Rb1, may be dependent on the composition of gut microbiota, including Bacteroides spp. and Bifidobacterium spp. Bacteroides and Bifidobacteria have been shown to be enhanced following Ambrotose intake, making Ambrotose a perfect pairing with this product.
    • Pair with Ambrotose and/or GI-ProBalance powders for optimal benefits
    • GINMAX is standardized to contain key ginsenosides and ginsenoside metabolites, including Rb1 and compound K
    • Fermented ginseng high in compound K may be more [potent/beneficial] than standard fermented red ginseng
    • Rb1 is metabolized to compound K in the gut
    • When compared with standard red ginseng intake, intake of fermented red ginseng results in higher levels of the key bioactive metabolite, compound K, the blood
    • Fermented red ginseng may be more [potent/beneficial] than traditional red ginseng
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