Grape extract (seed & skin). Grapes, the fruit of the grape vine Vitis vinifera, are the leading fruit crop in the world. Although they are popular as a fresh fruit, grapes are also used to make juices, jams, jelly, raisins and wine 1. Many health benefits provided by grapes and their products are attributed to their abundant polyphenols. The polyphenols in grapes include resveratrol and flavonoids: quercetin (and its glycoside, rutin), kaempferol, anthocyanins, tannins and myricetin. These compounds are present in the skins, seeds and stems of the grape and many demonstrate potent antioxidant activity 2. Grapes also contain plant acids, sugars, amino acids, minerals and small amounts of vitamins C and E 3, 4. Grape seed extract and grape skin extract are considered generally recognized as safe (GRAS) by the U.S. Food and Drug Administration (FDA) for use as food additives 5.