Grape pomace. Grapes, the fruit of the grape vine Vitis vinifera, are the leading fruit crop in the world. Although they are popular as a fresh fruit, grapes are also used to make juices, jams, jelly, raisins and wine 1. Grape pomace is defined as the pulp, peel, seeds and stalks that remain after oil, water or other liquids have been pressed out. Many health benefits provided by grapes and their products are attributed to their abundant polyphenols. The polyphenols in grapes include resveratrol and flavonoids: quercetin (and its glycoside, rutin), kaempferol, anthocyanins, tannins and myricetin. These compounds are present in the skins, seeds and stems of the grape and many demonstrate potent antioxidant activity 2. Grapes also contain plant acids, sugars, amino acids, minerals and small amounts of vitamins C and E 3, 4. The U.S. Food and Drug Administration (FDA) has been notified that industry considers grape pomace extract to be generally recognized as safe (GRAS) for use as an antioxidant in beverages and has not objected to its use for this purpose (GRN No.125).