Hydroxypropyl methylcellulose

Hydroxypropyl methylcellulose (HPMC), also known as hypromellose, is a derivative of cellulose. In oral products, HPMC is primarily used as a binder and for encapsulation as an alternative to animal-derived gelatin. In foods, it is used as a thickener and to stabilize oil-in-water mixtures 1, 2. Hydroxypropyl methylcellulose is an approved food additive by the U. S. Fod and Drug Administration (FDA)(21CFR172.874) 3, 4.

This ingredient can be found in the following products in United States:


  1. Handbook of Pharmaceutical Excipients. Washington, DC: Pharmaceutical Press and American Pharmacists Assn, 2006.
  2. Rowe RC, Sheskey PJ, Quinn ME (Eds). Handbook of Pharmaceutical Excipients. 6th Ed. American Pharmacists Assn (, Washington, DC and Pharmaceutical Press, London, UK; 2009; pp. 326-329. or or
  3. U. S. Food and Drug Administration (FDA). Electronic Code of Federal Regulations (e-CFR). 21e-CFR172.874 Hydroxypropyl methylcellulose. Current as of 6/17/2019. Accessed 6/19/2019.
  4. U. S. Food and Drug Administration (FDA). Code of Federal Regulations. Title 21. 21CFR172.874. Hydroxypropyl methylcellulose. Revised 4/1/2018. Updated 9/04/2018.