Lactoferrin is an iron-binding glycoprotein found in many bodily fluids such as milk, colostrum, saliva, tears and bile. It is a component of the innate immune response, acting as part of the body’s first line of defense against infection 1. For use in supplements, bovine lactoferrin can be purified from milk or milk derivatives, such as whey protein. The U.S. Food and Drug Administration (FDA) has been notified that industry considers milk-derived lactoferrin to be generally recognized as safe (GRAS) for use as an ingredient in sports and functional foods and has not objected to its use for this purpose (GRN No. 000077).