Safflower oil is derived from the seeds of the safflower plant, Carthamus tinctorius. It has been cultivated in Asia, Europe and the Americas for centuries. Safflower oil is utilized as a low in saturated fat cooking oil and in the production of margarine, as well as consumed as a dietary supplement. It is a rich source of the essential omega-6 fatty acid, linoleic acid 1. Safflower oil is likely safe when used orally and appropriately 2.