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Ingredient:

Salacia chinensis extract (root)

Salacia L. (family-Hippocrateaceae) is a genus widely found in Sri Lanka, China, India and other Asian countries 1. Additionally, S. chinenis Linn (Family Celastra) is commonly called Saptachakra or Saptarangi and one of the places it is found is in the semi-evergreen forests of the Western Ghats, India 1. The seeds are surrounded by an edible sweet, translucent and jelly-like pulp 1. S. chinensis as well as numerous species of the genus have been used in traditional Chinese herbs and botanicals for thousands of years as a food supplement or other use 1 and also has been used in Ayurvedic practices 2. Known phytochemicals have been reported in the leaves and roots S. chinensis 1, 3, 4. Active ingredients isolated from Salacia species, for the plant species S. chinensis, includes gomisins, pregomisin, deoxyschisandrin, and lignans schisandrin 5. The presence of certain bioactive molecules also includes mangiferin, salacinol, kotanalol, oleanolic acid, and morolic acid 1, 3, 4 and the roots of S. chinensis Linn contain phenolic compounds, triterpenes, and glycosides 2. S. chinensis extract and other Salacia species have been shown to be distinctly safe in animal studies 5 Salacia is likely safe when used orally 6 as evidenced by single doses up to 1,000 mg 6, 7, 8

This ingredient can be found in the following products in United States:

References

  1. Ghadage DM, Kshirsagar PR, Pai SR, Chavan JJ. Extraction efficiency, phytochemical profiles and antioxidant properties of different parts of Saptarangi (Salacia chinensis L.) – An important underutilized plant. Biochemistry and Biophysics Reports 2017; 12:79-90. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613233/
  2. Deokate UA, Khadabadi SS. Phytopharmacological aspects of Salacia chinensis. Journal of Pharmacognosy and Phytotherapy 2012; 4(1): 1-5. http://www.academicjournals.org/app/webroot/article/article1379604011_Deokate%20and%20Khadabadi.pdf
  3. Yoshikawa M, Nishida N, Shimoda H, Takada M, Kawahara Y, Matsuda H. [Abstract]. [Article in Japanese]. Polyphenol constituents from Salacia species: quantitative analysis of mangiferin with alpha-glucosidase and aldose reductase inhibitory activities. Yakugaku Zasshi 2001; 121:371-378.
  4. Minh TT, Anh NTH, Thang FD, Van Sung T. [Abstract]. Study on chemical constituents and cytotoxic activities of Salacia chinensis growing in Vietnam. Z Nat 2010;65b:1284-1288. https://doi.org/10.1002/chin.201108194
  5. Stohs S. J., and Ray S. Anti‐diabetic and Anti‐hyperlipidemic Effects and Safety of Salacia reticulata and Related Species. Phytother. Res 2015; 29: 986–995. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033029/ or https://doi.org/10.1002/ptr.5382
  6. Salacia. Natural Medicines Databases – Professional. Product ID No. 1106. Subscription required. Reviewed 7/24/2018. Updated 3/1/2019. Accessed 6/3/2019. https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=1106
  7. Heacock PM, Hertzler SR, Williams JA, Wolf BW. Effects of a medical food containing an herbal alpha-glucosidase inhibitor on postprandial glycemia and insulinemia in healthy adults. J Am Diet Assoc 2005;105:65-71. https://www.ncbi.nlm.nih.gov/pubmed/15635348?dopt=Abstract
  8. Collene AL, Hertzler SR, Williams JA, Wolf BW. Effects of a nutritional supplement containing Salacia oblonga extract and insulinogenic amino acids on postprandial glycemia, insulinemia, and breath hydrogen responses in healthy adults. [Abstract]. Nutrition 2005;21:848-54 https://www.ncbi.nlm.nih.gov/pubmed/15975493?dopt=Abstract