MannatechScience.com

Ingredient:

Trametes versicolor (Turkey tail)(as Peak02)

Trametes versicolor is a common mushroom found where there are decomposing hard wood logs or tree stumps and is used for health promotion and nutrition 1, 2, 3. Trametes versicolor is also called Coriolus versicolor, Polyporus versicolor, Polystictus versicolor, and Boletus veriscolor 1. Geographically, Coriolus versicolor is referred to as Kawartake, or mushrooms by the river bank (in Japan), Turkey tail in western cultures (North America) 4, and Yun Zhi, or “cloud like” mushroom (in China) 3, 4, 5. Coriolus versicolor (Trametes versicolor) is used as biomass or extract of the fruiting bodies, which contains primordia and mycelia 1, 2. The biomass form and the extract form of Trametes versicolor both provide B-glucans (i.e. grifolan, schizophyllan, lentinan) 2. The bioactive components of Trametes versicolor extracts include two polysaccharopeptides (PSPs), or bioactive agents, that comes from two different strains: In China, COV-1 (PSP, polysaccharide peptide) is used and in Japan, CM101 (polysaccharide krestin, PSK) is commonly used 3, 4, 6, both of which are for health promotion 1. For standardization and formulation purposes, one clinical study of water extract of the fruiting bodies of Trametes versicolor mushroom was shown to contain 33.8% total polysaccharides 1, 3 and the other study showed a water-soluble extract of Polysaccharide peptide (PSP) was composed of 10% peptides and 90% polysaccharides 1, 6. Polysaccharides and bioactive compounds play a role in immune health and may help lessen feelings of physical and psychological stresses, like fatigue 7. Studies conducted with Cordyceps militaris and a mushroom blend (PeakO2TM) determined benefits for athletic performance included improving VO2 max (maximal oxygen consumption), thus delaying fatigue (increasing time to exhaustion) and improving oxygen kinetics, positively impacting aerobic exercise of high-intensity 8.

This ingredient can be found in the following products in United States:

References

  1. Natural Medicines. Coriolus versicolor. Professional Monograph. Product ID No. 648. Reviewed 3/4/2019. Updated 3/11/2019. Accessed 5/10/2019. Subscription required for access. https://naturalmedicines.therapeuticresearch.com/references.aspx?productid=648
  2. Barros AB, Ferrao J, Fernandes T. A safety assessment of coriolus versicolor biomass as a food supplement. Food Nutr Res 2016; 10;60:29953. https://www.ncbi.nlm.nih.gov/pubmed/26969586 or https://doi.org/10.3402/fnr.v60.29953
  3. Hor SY, Ahmad M, Farsi E, Lim CP, Asmawi MZ, Yam MF. Acute and subchronic oral toxicity of Coriolus versicolor standardized water extract in Sprague-Dawley rats. [Abstract]. J Ethnopharmacol 2011;137(3):1067-76. https://www.ncbi.nlm.nih.gov/pubmed/21767625?dopt=Abstract or https://doi.org/10.1016/j.jep.2011.07.007
  4. Saleh MH, Rashedi I, Keating A. Immunomodulatory properties of Coriolus versicolor: The role of polysaccharopeptide. Front Immunol 2017; 8: 1087. https://www.ncbi.nlm.nih.gov/pubmed/28932226 or https://doi.org/10.3389/fimmu.2017.01087
  5. Knezevic A, Zivkovic L, Stajic M, Vukojevic J, Milovanovic I, Spremo-Potparavic B. Antigenotoxic effect of Trametes spp. Extracts against DNA damage on human peripheral White Blood Cells Scientific World Journal 2015; 2015: 146378 https://www.ncbi.nlm.nih.gov/pmc/PMC4517545 or https://doi.org/10.1155/2015/146378
  6. Yeung JH, Or PM. Polysaccharide peptides from Coriolus versicolor competitively inhibit tolbutamide 4-hydroxylation in specific human CYP2C9 isoform and pooled human liver microsomes. [Abstract]. Phytomedicine 2011; 18(13):1170-5. https://www.ncbi.nlm.nih.gov/pubmed/21757329?dopt=Abstract
  7. Geng P, Siu K-C, Wang Z, Wu J-&. . Antifatigue functions and mechanisms of edible and medicinal mushrooms. Biomed Research International, vol. 2017, Article ID 9648496, 16 pages, https://doi.org/10.1155/2017/9648496
  8. Hirsch KR, Mock MG, Roelofs EJ, Trexler ET, Smith-Syran, AE. Chronic supplementation of a mushroom blend on oxygen kinetics, peak power, and time to exhaustion. (Poster Session). Journal of the International Society of Sports Nutrition 2015; 12(Suppl 1), P45. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594151