Vitamin B6 (as pyridoxal-5-phoshate)
Vitamin B6 or Pyridoxal-5-Phosphate is a form of vitamin B6 used in fortified foods and nutritional supplements 1,2,4. Pyridoxal-5-phospate is considered generally recognized as safe (GRAS) for use as a direct food ingredient by the U. S. Food and Drug Administration (FDA)(21CFR184.1676) 10. P5P, is a water-soluble vitamin that functions as a coenzyme 1,2,3,4 in the metabolism of amino acids and the release of glucose from glycogen 1,2,4,5 and vitamin B6 is involved in over 100 enzyme reactions 2.* Vitamin B6 must be obtained from the diet because humans cannot produce (synthesize) it 1. Major sources of vitamin B6 include fortified, ready-to-eat cereals; mixed foods (including sandwiches) with meat, fish or poultry as the main ingredient; white potatoes and other starchy vegetables; and non-citrus fruits 1,4,6. Vitamin B6 is frequently used in combination with other B vitamin in vitamin B complex formulations 2,3. Vitamin B6 is generally considered safe in adults and children when used appropriately at recommended doses 2,3.
The U. S. Food and Drug Administration (FDA) has established a Reference Daily Intake (RDI) of 2.0 mg (to be updated to 1.7 mg in 2020) vitamin B6 for adults and children 4 or more years of age (21CFR101.9) 7,8,9. RDIs are a set of dietary references for essential vitamins and minerals that are considered amounts sufficient to meet the daily requirements of healthy individuals 4,7,9. RDIs serve as a basis for calculating the percent daily value (%DV) amounts found on dietary supplement and food labels 4,8.
This ingredient can be found in the following products in United States:
- Catalyst™ Multivitamin Tablets
- Food and Nutrition Board (FNB). Institute of Medicine (IOM). Dietary Reference Intakes (DRIs) for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. http://books.nap.edu/books/0309065542/html and https://www.nap.edu/read/6015/chapter/9
- Natural Medicines database. Professional monograph. Vitamin B6. Product ID no. 934. Last reviewed 2/22/2019. Last updated 2/19/2019. Subscription required. https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=934
- U. S. National Library of Medicine (NLM). National Institutes of Health (NIH). MedlinePlus. Vitamin B6. Last updated 1/28/2019. Last reviewed https://medlineplus.gov/ency/article/002402.htm and https://medlineplus.gov/druginfo/natural/934.html
- U. S. Department of Health and Human Services (HHS). National Institutes of Health (NIH). Office of Dietary Supplements (ODS). Vitamin B6. Fact Sheet for Health Professionals. Updated 9/27/2018. https://ods.od.nih.gov/factsheets/VitaminB6-HealthProfessional/
- Mackey AD, et al. Vitamin B6, In: Shils, ME, Shike M, Ross AC, Caballero B, Cousins RD, Eds. Modern Nutrition in Health and Disease. 10th Ed. Philadelphia: Lippincott Williams & Wilkins;2005:452-461.
- Ross A, Caballero B, Cousins R, Tucker K, Ziegler T. Vitamins. In: Modern Nutrition in Health and Disease 2014; (11th ed., pp. 343-345). Philadelphia: Lippincott Williams & Wilkins.
- Dietary Supplement Label Database. National Institutes of Health (NIH). A joint effort of the Office of Dietary Supplements (ODS) and the National Library of Medicine (NLM). https://www.dsld.nlm.nih.gov/dsld/dailyvalue.jsp
- U. S. Food and Drug Administration (FDA). Dietary Supplement Labeling Guide: Appendix B. Daily Values for Adults and Children 4 or more years of age. Last updated: 3/21/2018. https://www.fda.gov/Food/GuidanceRegulation/GuidanceDocumentsRegulatoryInformation/DietarySupplements/ucm070617.htm
- U. S. Department of Health and Human Services (DHHS). National Institutes of Health (NIH). Office of Dietary Supplements (ODS). Strengthening knowledge and understanding of dietary supplement. Health information. Daily Values (DVs). https://ods.od.nih.gov/HealthInformation/dailyvalues.aspx
- U. S. Food and Drug Administration (FDA). Electronic Code of Federal Regulations (eCFR). 21CFR 184.1676. Vitamin B6. 10/20/1995 and Amended/Updated 3/7/2013. https://www.ecfr.gov/cgi-bin/retrieveECFR?gp=&SID=7e96f3c7483b6640ee670a1d9d9404ff&mc=true&n=sp21.3.184.b&r=SUBPART&ty=HTML#se21.3.184_11676