Vitamin B6 (as pyridoxal-5-phoshate)

Vitamin B6 or Pyridoxal-5-Phosphate is a form of vitamin B6 used in fortified foods and nutritional supplements 1,2,4. Pyridoxal-5-phospate is considered generally recognized as safe (GRAS) for use as a direct food ingredient by the U. S. Food and Drug Administration (FDA)(21CFR184.1676) 10. P5P, is a water-soluble vitamin that functions as a coenzyme 1,2,3,4 in the metabolism of amino acids and the release of glucose from glycogen 1,2,4,5 and vitamin B6 is involved in over 100 enzyme reactions 2.* Vitamin B6 must be obtained from the diet because humans cannot produce (synthesize) it 1. Major sources of vitamin B6 include fortified, ready-to-eat cereals; mixed foods (including sandwiches) with meat, fish or poultry as the main ingredient; white potatoes and other starchy vegetables; and non-citrus fruits 1,4,6. Vitamin B6 is frequently used in combination with other B vitamin in vitamin B complex formulations 2,3. Vitamin B6 is generally considered safe in adults and children when used appropriately at recommended doses 2,3.

The U. S. Food and Drug Administration (FDA) has established a Reference Daily Intake (RDI) of 2.0 mg (to be updated to 1.7 mg in 2020) vitamin B6 for adults and children 4 or more years of age (21CFR101.9) 7,8,9. RDIs are a set of dietary references for essential vitamins and minerals that are considered amounts sufficient to meet the daily requirements of healthy individuals 4,7,9. RDIs serve as a basis for calculating the percent daily value (%DV) amounts found on dietary supplement and food labels 4,8.

This ingredient can be found in the following products in United States:


  1. Food and Nutrition Board (FNB). Institute of Medicine (IOM). Dietary Reference Intakes (DRIs) for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. and
  2. Natural Medicines database. Professional monograph. Vitamin B6. Product ID no. 934. Last reviewed 2/22/2019. Last updated 2/19/2019. Subscription required.,-herbs-supplements/professional.aspx?productid=934
  3. U. S. National Library of Medicine (NLM). National Institutes of Health (NIH). MedlinePlus. Vitamin B6. Last updated 1/28/2019. Last reviewed and
  4. U. S. Department of Health and Human Services (HHS). National Institutes of Health (NIH). Office of Dietary Supplements (ODS). Vitamin B6. Fact Sheet for Health Professionals. Updated 9/27/2018.
  5. Mackey AD, et al. Vitamin B6, In: Shils, ME, Shike M, Ross AC, Caballero B, Cousins RD, Eds. Modern Nutrition in Health and Disease. 10th Ed. Philadelphia: Lippincott Williams & Wilkins;2005:452-461.
  6. Ross A, Caballero B, Cousins R, Tucker K, Ziegler T. Vitamins. In: Modern Nutrition in Health and Disease 2014; (11th ed., pp. 343-345). Philadelphia: Lippincott Williams & Wilkins.
  7. Dietary Supplement Label Database. National Institutes of Health (NIH). A joint effort of the Office of Dietary Supplements (ODS) and the National Library of Medicine (NLM).
  8. U. S. Food and Drug Administration (FDA). Dietary Supplement Labeling Guide: Appendix B. Daily Values for Adults and Children 4 or more years of age. Last updated: 3/21/2018.
  9. U. S. Department of Health and Human Services (DHHS). National Institutes of Health (NIH). Office of Dietary Supplements (ODS). Strengthening knowledge and understanding of dietary supplement. Health information. Daily Values (DVs).
  10. U. S. Food and Drug Administration (FDA). Electronic Code of Federal Regulations (eCFR). 21CFR 184.1676. Vitamin B6. 10/20/1995 and Amended/Updated 3/7/2013.