Review of the Effects of Polysaccharides on Brain Function is Published. Mechanisms That Might Explain the Cognitive Benefits of Glyconutrients and Other Polysaccharides are Explored.
While there is growing interest in the effect of oral polysaccharide on health, studies assessing their effect on neurologic function have never been consolidated. Now, a comprehensive literature review has been published that brings together this interesting literature. Dr. Erika Nelson, a neuroscientist, and her colleagues limited their review to controlled studies assessing various roles of exogenous saccharide compounds and polysaccharide-rich extracts on brain function, with a significant focus on benefits derived from oral intake. Six randomized, double-blind, placebo-controlled clinical trials were found that indicate that certain oral polysaccharides positively impact well-being, cognitive function and mood in healthy adults. The most promising human clinical research in this area has been conducted on Ambrotose® complex.* Numerous preclinical studies were also identified that indicate that polysaccharides can modify behavior, enhance synaptic plasticity and provide neuroprotective effects. Dr. Nelson earned her BS in Genetics from the University of Kansas in Lawrence and went on to obtain her PhD in Neuroscience at the University of Texas Southwestern Medical Center in Dallas. She has published a number of papers on neurodevelopmental disorders and brain epigenetics. A candidate for a Masters of Business Administration at the University of Texas at Dallas, Dr. Nelson is also a consultant for Mannatech, Incorporated. Co-authors include Dr. Robert A. Sinnott, CEO and CSO at Mannatech; Dr. Talitha Best, a scientist with dual appointments at the University of South Australia, Adelaide, and Swinburne University of Technology, Victoria, Australia; and Jane Ramberg, Director of Product Substantiation at Mannatech.Publications