In an open-label, controlled human study conducted by Roca** et al.*** (2019), 20 participants, the active group, received a polysaccharide-based multi-ingredient supplement of 8 g/day Advanced Ambrotose® complex powder, (AA), (with Arabinogalactan, Aloe Vera extract, rice starch, ghatti gum, gum Tragacanth, Glucosamine HCl, Wakame algae extract), taken for 15 days prior to the marathon while the other 21 participants, the control group, received no supplement. Results showed that in the active group there were significant changes in salivary and systemic immunological biomarkers before as well as after the race. The authors’ findings suggest that Advanced Ambrotose may have a positive effect on immune response after a strenuous exercise.

**Emma Roca, M. S. in Biochemistry and Molecular Biology, is a doctoral candidate for a Biochemistry, PhD, to be achieved in June 2019.
***Author/author affiliations are below:

This study was funded by an unconditional product grant from Mannatech, Inc. (Flower Mound, TX—previously Coppell, TX). The researchers in this study independently collected, analyzed, and interpreted the results from this study and have no financial interests in the results of this study.

1 Emma Roca, Doctoral Candidate and Dr. Lexa Nescolarde, Research Centre for Biomedical Engineering, Universitat Politècnica de Catalunya, Jordi Girona, 1-3, 08034 Barcelona, Spain.
2 Dr. Elisabet Canto, Dr. Lidia Perea, and Dr. Silvia Vidal, Laboratory of Experimental Immunology, Biomedical Research Institute Sant Pau (IIB Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Catalonia, Spain.
3 Dr. Lexa Nescolarde, Department of Electronic, Universitat Politècnica de Catalunya, Barcelona,Spain.
4,5,6 Dr. Antoni Bayes-Genis, Department of Cardiology, Hospital Universitari Germans Trias i Pujol, Badalona, Spain; Department of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain; Research Program, Fundació Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol, Badalona, Spain.
7 Dr. Oriol Sibila, Respiratory Department, Hospital de la Santa Creu i Sant Pau, Autonomous, University of Barcelona and Biomedical Research Institute Sant Pau (IIB SantPau), Barcelona, Catalonia, Spain.


Roca E1, Canto E2, Nescolarde L1,3, Perea L2, Bayes-Genis A4,5,6, Sibila O7, Vidal S2 (2019). Effects of a polysaccharide-based multi-ingredient supplement on salivary immunity in non-elite marathon runners. J Int Soc Sports Nutr 16:14

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