Scientists at ProDigest in collaboration with the Laboratory of Microbial Ecology and Technology (LabMET) at Ghent University, in Belgium conducted this study, the first to apply 16sRNA genes-based pyrosequencing in a Simulator of the Human Intestinal Microbial Ecosystem (SHIME) study. The pyrosequencing technique allowed the scientists to explore more deeply and confirm findings from a previous Ghent University study which showed that Advanced Ambrotose powder exhibited prebiotic effects along the entire colon. Study was at least partially funded by Mannatech.


Marzorati M, Maignien L, Verhelst A et al. (2013) Barcoded pyrosequencing analysis of the microbial community in a simulator of the human gastrointestinal tract showed a colon region-specific microbiota modulation for two plant-derived polysaccharide blends. Antonie Van Leeuwenhoek. 103(2):409-20.

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